Clinical Trial Summary
Kikuchi-Fujimoto disease is a distinctive syndrome of necrotizing lymphadenitis which was
formally described in 1972 by two Japanese pathologists, Kikuchi and Fujimoto. It is a
benign, self-limited disease that predominantly occurs in young women. It was more common in
Asian people, especially in Japanese. The most frequent clinical presentations are fever
(30~50%) and cervical lymphadenopathy, often tender in palpable. Other lymph node regions
can be affected, and hepatosplenomegaly may be present. The laboratory findings include
leucopenia with atypical lymphocytosis. ESR, transaminases and lactate dehydrogenase are
often raised. The clinical features are easily confused with other conditions, particularly
lymphoma. Therefore the diagnosis depends on the pathological findings. The typical findings
are paracortical lesions consisting of patchy zones of eosinophilic fibrinoid necrosis and
abundant karyorrhexis. In general, spontaneous resolution of symptoms and signs within a few
months can be expected without treatment.For decades, the etiology of Kikuchi's disease has
been speculated. Although the perforin and Fas pathways of cytotoxic T cells induce an
abundance of apoptosis and thus induce necrotizing lesions, the trigger factor is unknown.
Since the disease can precede or occur in association with a connective tissue disorder,
especially SLE, the autoimmune contribution to the etiology has also been speculated.
However, the clinical course of Kikuchi's disease, often sudden onset and spontaneous
resolution, the frequent flu-like or upper respiratory prodrome, and the prominence of
cervical lymphadenopathy, support a viral cause. Evidence for a viral cause also includes
peripheral blood atypical lymphocytosis and elevated serum IFN-a or 2`-5` oligoadenylate
synthetase levels. Several infectious agents have been suggested, including bacteria (e.g.
Brucella, Yersinia), parasites (e.g. toxoplasmosis) and viruses (e.g. EBV, CMV, HHV6, HHV8,
parvovirus B19, HTLV, HIV).The aim of this study is to collect cases of Kikuchi' disease in
bureau of NHI and NTUH. We will analyze the incidence rate, age of onset, sex, season of
onset and clinical course to see if there is any clustered cases, or nosocomial infection.
Then we will study the etiology of Kikuchi's disease especially the infection causes by
analyzing pathologic specimen and serology. We hope to find out the etiology of Kikuchi's
disease and the new treatment.
