Lymph Node Excision Clinical Trial
Official title:
A Prospective and Multi-center RCT Study of Lymphadenectomy Based on Intraoperative Frozen Pathology for Pulmonary Invasive Adenocarcinoma Presenting With Ground Glass Opacity
The purpose of this study is to evaluate the impact of systematic sampling of lymph nodes vs. lymphadenectomy on outcome according to intraoperative frozen pathology for pulmonary invasive adenocarcinoma with ground-glass opacity (GGO) after VATS lobectomy.
On HRCT screening, early lung adenocarcinoma often contains a nonsolid component called
ground-glass opacity (GGO). In 2011, pulmonary adenocarcinomas were classified into atypical
adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive carcinoma
(MIA) and more extensively invasive adenocarcinoma (IAC) [1]. Early adenocarcinomas with
GGO-dominant always mean low-grade malignancy and have an extremely favorable prognosis
[2-5]. Previous studies have shown that patients with AAH, AIS and MIA have excellent
survival rates (5-year survival rate is approximate 95%) after resection, and only 0.83% -
2.91% patients have lymph node metastasis [6-9]. At present, lymphadenectomy is always
undergone in patients with pulmonary adenocarcinoma with ground-glass opacity. However, for
MIA patients (especially in T1a-b stage), the appropriate use of lymphadenectomy continues to
be debated.
Nowadays, intraoperative frozen pathology is widely used during operation. However, whether
sampling of lymph nodes or lymphadenectomy should be performed for GGO lesions according to
intraoperative pathological diagnosis is unclear. The aim of this prospective study is to
evaluate whether there are any trends regarding the impact of subtypes of invasive
adenocarcinoma according to intraoperative frozen pathology in sampling of lymph nodes vs.
lymphadenectomy.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05730595 -
Fluorescence Laparoscopic Navigation for Rectal Cancer and Sigmoid Colon Cancer
|
N/A | |
| Recruiting |
NCT04631770 -
Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC
|
N/A | |
| Completed |
NCT06385912 -
Systematic Lymphadenectomy During Interval Debulking Surgery in Advanced Epithelial Ovarian Cancer
|
||
| Not yet recruiting |
NCT05129774 -
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
|
N/A |