Lyme Disease Clinical Trial
Official title:
Comparative Study of Peripheral Facial Paralysis Sequelae Based on the Initial Medical Care of Lyme Disease Among Children
Neuroborreliosis (NB) is the second most frequent manifestation of Lyme disease. Painful
meningoradiculitis is the most common neurologic manifestation in adults while facial nerve
palsy (FP) and lymphocytic meningitis is predominant in children. FP is a common reason for
pediatric consultation and FP due to Lyme borreliosis (LB) represents about 50% of the
child's FP in an endemic area.
The action to be taken is not formally defined for a child consulting for FP in a Lyme
disease endemic area.
The new recommendations of the High Authority of Health of June 2018 recommend to carry out a
blood serology in first intention, in search of a NB in a child consulting for a peripheral
facial paralysis. If this is positive, a lumbar puncture will be performed in search of
meningitis. In the case of negative serology, a close clinical surveillance and sometimes
serological control is necessary, in order to reassess the diagnosis. In adult
recommendations, a lumbar puncture is performed first in any patient consulting for facial
paralysis in LB endemic area.
The main objective of this study was to describe the clinical and biological characteristics
of pediatric NB with FP. Others objectives were to describe the diagnostic and therapeutic
behavior of a child consulting at university hospital for a facial nerve palsy, to compare
the initial gravity of facial nerve palsy, the duration of the paralysis and sequels
depending on the diagnosis and treatment initiated.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01207739 -
Persistent Lyme Empiric Antibiotic Study Europe
|
Phase 4 | |
| Terminated |
NCT04577053 -
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
|
N/A | |
| Completed |
NCT04867473 -
Feasibility of Teleyoga for Treatment of Lyme Disease
|
N/A | |
| Recruiting |
NCT04038346 -
Symptomatic Management of Lyme Arthritis
|
Phase 3 | |
| Completed |
NCT01143558 -
Searching for Persistence of Infection in Lyme Disease
|
Early Phase 1 | |
| Withdrawn |
NCT04318925 -
Evaluation and Follow-up of People With Tick-borne Diseases
|
||
| Terminated |
NCT03581279 -
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
|
N/A | |
| Enrolling by invitation |
NCT05041595 -
Lyme Disease Diagnostic Assay - Collection of Whole Blood
|
||
| Recruiting |
NCT03963635 -
Novel Diagnostics for Early Lyme Disease
|
||
| Terminated |
NCT03084614 -
CD8 Reactivity to Microorganisms in Blood and Breast Milk
|
||
| Recruiting |
NCT04835792 -
Biomarker Study of Previously Treated Lyme Disease Volunteers in Comparison to Healthy Volunteers
|
||
| Recruiting |
NCT06397794 -
Navigating Pregnancy and Parenthood With Lyme Disease
|
||
| Recruiting |
NCT04148222 -
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
|
||
| Terminated |
NCT03201042 -
Lyme Test Indication Combinations (LyTIC) Study
|
||
| Completed |
NCT01368341 -
Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice
|
Phase 4 | |
| Terminated |
NCT00958139 -
Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes
|
Phase 3 | |
| Recruiting |
NCT00001539 -
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
|
||
| Recruiting |
NCT03501407 -
Understanding Tick-borne Diseases
|
||
| Completed |
NCT04422314 -
ImmuneSense Lyme Study
|
||
| Recruiting |
NCT05312619 -
The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Cohort Survey
|