Lyme Disease Clinical Trial
Official title:
Study and Treatment of Post Lyme Disease (STOP-LD)
The purpose of this study is to see how well antibiotics work in reducing chronic fatigue symptoms, such as tiredness, in patients that were treated for Lyme Disease. Fatigue is a common symptom of Lyme Disease. When fatigue does not improve after treatment, patients are considered to have Post Lyme Syndrome (PLS). The chronic fatigue seen in these patients appears to be related to the initial infection which causes Lyme Disease. It is believed, but not proven, that treatment with antibiotics may be effective in relieving chronic fatigue in PLS patients.
You will be assigned randomly (like tossing a coin) to receive either antibiotics or a placebo (sugar pill). Neither you nor your doctor will know which you are receiving. You will learn to give yourself the injection, and you will remain on your study drug for 28 days. A home health care nurse will visit you twice a week to check the injection site, and at weeks 1 and 3 the nurse will draw blood for laboratory tests. At months 1 and 6, you will be examined to see if you have fewer chronic fatigue symptoms after the antibiotics. This will include a fatigue questionnaire, a test of your mental processing speed, and a test of your cerebrospinal fluid. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01207739 -
Persistent Lyme Empiric Antibiotic Study Europe
|
Phase 4 | |
| Terminated |
NCT04577053 -
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
|
N/A | |
| Completed |
NCT04867473 -
Feasibility of Teleyoga for Treatment of Lyme Disease
|
N/A | |
| Recruiting |
NCT04038346 -
Symptomatic Management of Lyme Arthritis
|
Phase 3 | |
| Completed |
NCT01143558 -
Searching for Persistence of Infection in Lyme Disease
|
Early Phase 1 | |
| Withdrawn |
NCT04318925 -
Evaluation and Follow-up of People With Tick-borne Diseases
|
||
| Terminated |
NCT03581279 -
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
|
N/A | |
| Enrolling by invitation |
NCT05041595 -
Lyme Disease Diagnostic Assay - Collection of Whole Blood
|
||
| Recruiting |
NCT03981874 -
Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children
|
N/A | |
| Recruiting |
NCT03963635 -
Novel Diagnostics for Early Lyme Disease
|
||
| Terminated |
NCT03084614 -
CD8 Reactivity to Microorganisms in Blood and Breast Milk
|
||
| Recruiting |
NCT04835792 -
Biomarker Study of Previously Treated Lyme Disease Volunteers in Comparison to Healthy Volunteers
|
||
| Recruiting |
NCT06397794 -
Navigating Pregnancy and Parenthood With Lyme Disease
|
||
| Recruiting |
NCT04148222 -
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
|
||
| Terminated |
NCT03201042 -
Lyme Test Indication Combinations (LyTIC) Study
|
||
| Completed |
NCT01368341 -
Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice
|
Phase 4 | |
| Terminated |
NCT00958139 -
Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes
|
Phase 3 | |
| Recruiting |
NCT00001539 -
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
|
||
| Recruiting |
NCT03501407 -
Understanding Tick-borne Diseases
|
||
| Completed |
NCT04422314 -
ImmuneSense Lyme Study
|