T Regulatory Cells IN LUPUS NEPHRITIS

Status Not yet recruiting

Clinical Trial Summary

- To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs . - To compare the functional capacity of T regs in LN and in normal individuals.

Clinical Trial Description

Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06428539
Study type	Observational
Source	Assiut University
Contact	Mohamed AH Hussein
Phone	+966554599271
Email	mohammedaggag30@gmail.com
Status	Not yet recruiting
Phase
Start date	July 1, 2024
Completion date	August 1, 2025

View Details

See also
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