| Eligibility |
Inclusion Criteria:
- 1. Able to sign Informed Consent Form (ICF) ;
- 2. Males or females 18-70(include 18 and 70) years of age;
- 3. Have a clinical diagnosis of SLE according to the American College of Rheumatology
(ACR) 1997 or European League against Rheumatism(EULAR)/ the American College of
Rheumatology (ACR) 2019 criteria .Have a clinical diagnosis of SLE according to the
American College of Rheumatology (ACR) 1997 or European League against
Rheumatism(EULAR)/ the American College of Rheumatology (ACR) 2019 criteria .
Group1:Have active, biopsy-proven proliferative lupus nephritis Class III or IV, or Class V
using the 2003 ISN/RPS criteria. The biopsy must be performed in the 6 months prior to the
screening visit or during the screening period. Have documentation of active renal disease
defined as:24h Proteinuria> 1.5 grams/day.
Refractory lupus nephritis is defined as no induced remission to treatment regimens
containing at least one immunosuppressant (including glucocorticoids, CTX, tacrolimus, MMF,
and cyclosporine) after 3 to 6 months, accompanied by no reduction (or worsening) of
proteinuria or persistent antibody positives.
Group 2: Refractory thrombocytopenia: No response to treatment with at least 1 course of MP
shock (1g for 3 days) or high dose of glucocorticoids (1mg/kgd equivalent dose of
glucocorticoids) combined with 1 or more immunosuppressants. Before enrollment, at least 2
consecutive blood routine tests were performed to check platelets below 50×10^9/L and above
30×10^9/L. Other non-SLE causes of thrombocytopenia, such as infection, bone marrow
suppression, and hypersplenism, were excluded.
- 4. Not pregnant or nursing.
- 5. Adequate organ functions indicated as: ALT and AST < 3 times of the ULN; Total
bilirubin < 2mg/dL with the exception of patients with Gibert-Meulengracht syndrome,
who may be included if their total bilirubin is < 3 x ULN and direct bilirubin <
1.5mg/dL ULN; An estimated glomerular filtration rate < 30 mL/min/1.73 m^2 at the
screening visit Serum creatinine =1.5mg/dl(133umol/l); Must have a minimum level of
pulmonary reserve, non-oxygenated blood oxygen saturation >95%;
- 6. Lymphocyte count > 0.4×10^9/L;
- 7. Use a small dose of glucocorticoid (dose equivalent to =10mg/d prednisone) for not
less than 1 month (except glucocorticoid intolerance).
Exclusion Criteria:
- 1. Severe active central nervous system (CNS) lupus, including seizures, psychosis,
cerebrovascular accidents;
- 2. Dialysis patients or creatinine clearance rate < 30ml/min;
- 3. Pregnant or breast feeding;
- 4. Active infections (such as sepsis, bacteremia, fungemia, uncontrolled pulmonary
infection, and active tuberculosis);
- 5. One of the following: HBsAg positive HCV-Ab positive HIV positive TP positive
- 6. Undergone major surgery assessed by the subjects as unsuitable for inclusion within
4 weeks prior to screening.
- 7. Had or is currently suffering from other malignant tumors within five years prior
to screening, except for curable tumors with negligible risk of metastasis or death,
such as cervical carcinoma in situ and skin basal cell carcinoma with adequate
treatment;
- 8. The heart meets any of the following conditions: Left ventricular ejection fraction
(LVEF) =45%; New York Heart Association (NYHA) Class III or IV congestive heart
failure or active heart disease; Severe arrhythmias requiring treatment (except atrial
fibrillation and paroxysmal supraventricular tachycardia); QTcB interval male =450ms,
female =470ms (QTcB=QT/RR^1/2); Had a myocardial infarction, bypass, or stent surgery
within the 6 months prior to the study; Other heart diseases that the investigators
judged unsuitable for inclusion;
- 9. Received live vaccine within 6 weeks prior to screening;
- 10. Participants who have participated in other interventional clinical studies within
the 3 months prior to cell transfusion, received active investigational drug therapy,
or who intend to participate in another clinical trial or receive treatment outside
the protocol during the entire study period.
- 11. a history of epilepsy or other active central nervous system diseases;
- 12. Subjects who are known to have hypersensitivity to the ingredients of the
preparation used in the test;
- 13. Previously received CAR T cell therapy;
- 14. Other conditions deemed unsuitable for participation in this clinical trial by
subject.
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