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Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic Clinical Trial

Official title:
Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

Clinical Trial Summary

Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00008749
Study type Observational
Source National Center for Research Resources (NCRR)
Contact Randy Q Cron, MD, Ph.D.
Phone 215-590-1844
Status Recruiting
Phase N/A
View Details
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