Lung Transplantation Clinical Trial
Official title:
The Effects of Inspiratory Muscle Training on Physical Activity and Quality of Life in Lung Transplantation Candidates
Inspiratory Muscle Training (IMT), which is used to strengthen the respiratory muscles, is
one of the techniques used in PR. It is mostly used in patients with chronic obstructive
pulmonary disease, and has been shown to be beneficial for functionality and also for
relieving dyspnea perception. It is reported in the guidelines that IMT has additional
benefit for endurance in COPD patients. However, there are no studies related to its use and
effectiveness in lung transplantation. In this study, investigators hoped to increase these
known benefits by adding IMT to the standard Pulmonary Rehabilitation.
There are two main objectives of this study:
- to examine the effect of inspiratory muscle training on physical activity status and
quality of life in lung transplantation candidates,
- to compare physical activity and quality of life changes between the IMT+PR group and
the PR group
The patients in the lung transplantation waiting list were included the study. These patients
were with severe lung disease requiring transplantation, and that the intervention was
undertaken before any lung transplantation. The patients were eligible for inclusion if
participitants have: a diagnosis of terminally severe lung disease, being listed for lung
transplantation, medically stable, had no orthopedic or cardiac problems that would prevent
them from exercising and had no transfer problem to the PR centre.
Participants who meet the study inclusion criteria and complete the baseline assessments were
randomly allocated into one of the two groups: namely Pulmonary Rehabilitation plus
Inspiratory Muscle Training Group (IMT+PR) or Pulmonary Rehabilitation Group (PR) using a
numbered series of 34 prefilled envelops specifying group assignment generated by a
computer-based program.
All patients underwent supervised PR program on 2 days per week for 3 months. Apart from
that, participitant were asked to perform the home exercise program which was scheduled as 3
days per week and fill out the exercise follow-up form. The study group was provided with IMT
in addition to the standard program.
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