Lung Transplantation Clinical Trial
It is commonly accepted that the characteristics of the organ donor impact on the future
post transplant. In lung transplantation (LP), the defining characteristics of the "ideal"
donor includes an age less than 55 years. However, before the pulmonary graft shortage with
a corresponding mortality still too high waiting list, the lung graft acceptance criteria
were reassessed permitting criteria "extension" ( "marginal" graft). And were grafted,
depending on the urgency and accessibility problems in the registry of potential candidate,
organs from donors aged 55 and older with quite comparable to those obtained from younger
donors . Nevertheless, it is common practice that the grafts from older donors are more
readily allocated to older candidates and the most severe, as many confounding factors to
assess the real impact of donor age on post-transplant evolution on small cohorts.
The main goal of this study is to compare the survival of lung transplant patients depending
on the age difference between donor and recipient.
The study will be conducted from a broad national cohort of lung transplant patients
registered in COLT ( Lung Transplantation COhort). Established in September 2009, promoted
by the University Hospital of Nantes, COLT involves 11 lung transplant centers authorized on
French territory. It provides a standardized common longitudinal monitoring of the recipient
from his transplant. Currently more than 1,000 patients included in this study are
transplanted.
Status | Not yet recruiting |
Enrollment | 800 |
Est. completion date | April 2018 |
Est. primary completion date | October 2017 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Male or female adult patients, included in COLT cohort, thus having given a signed written consent - Who received a lung transplant Exclusion Criteria: - Lung transplanted patients in a context of national priority - Lung transplanted patients who died within 3 months after the surgery - Patients for whom it is a second lung transplantation |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
France | Assistance Publique Hôpitaux de Marseille, Hôpital Nord | Marseille Cedex 01 |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique Hopitaux De Marseille |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Age difference in years between donor and recipient | The age difference will then be able to define two groups of patients: 1 group with an age difference < 10 years 1 group with an age difference > 10 years |
1 day | Yes |
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