Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)

Status Recruiting

Clinical Trial Summary

Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection. Extracorporeal circuits may negatively affects pharmacokinetic (PK) of several drugs including antibiotics, thus exposing patients to risk of therapeutic failure or drug toxicity. The investigators set out to examine the concentration of imipenem in lung perfusate and in lung biopsy during EVLP, and its clinical impact.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Lung Transplantation

Clinical Trial Details

NCT number	NCT02670239
Study type	Observational
Source	University of Turin, Italy
Contact	Vito Fanelli, MD, PhD
Phone	0039011633
Email	vito.fanelli@unito.it
Status	Recruiting
Phase	N/A
Start date	May 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02581111` - Naloxone for Optimizing Hypoxemia Of Lung Donors	Phase 2/Phase 3
Recruiting	`NCT02177916` - Patient Education Study to Determine Knowledge Acquisition in Patients Preparing to Undergo Lung Transplantation	N/A
Not yet recruiting	`NCT01394835` - Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients	Phase 2
Completed	`NCT01204970` - Confocal Laser Micro-endoscopy in Chronic Obstructive Pulmonary Disease (COPD) and Lung Transplant Recipients	N/A
Not yet recruiting	`NCT01162148` - Pulmonary Rehabilitation and Inspiratory Muscle Training (IMT) for Patients Following Lung Transplantation	N/A
Active, not recruiting	`NCT00980967` - Predictive Factors for Chronic Rejection in Lung Transplant Recipients: COLT Study	N/A
Completed	`NCT00531921` - Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival	N/A
Recruiting	`NCT00163696` - Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease	N/A
Completed	`NCT00177684` - Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®)	Phase 3
Completed	`NCT00163891` - Comparison of Two Chest Physiotherapy Protocols in Lung Transplant Recipients	N/A
Completed	`NCT03668483` - Relation Between Muscle Strength With Exercise Capacity and Dyspnea in LTx	N/A
Not yet recruiting	`NCT02855372` - Impact of the Age Difference Between the Donor and Recipient on the Morbidity and Mortality After Lung Transplantation. Study on a National Multicenter Cohort (COLT)	N/A
Completed	`NCT01212406` - Vitamin D in Bronchiolitis Obliterans Syndrome	Phase 4
Completed	`NCT01211509` - Montelukast in Bronchiolitis Obliterans Syndrome	Phase 4
Not yet recruiting	`NCT00808600` - Empowerment of Lung and Heart-lung Transplant Patients	N/A
Completed	`NCT00553397` - Live Lung Donor Retrospective Study	N/A
Completed	`NCT00402805` - Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy	Phase 4
Terminated	`NCT00235651` - Abelcet Radiotagging Protocol: Inhaled Lipid Complex Abelcet® in Lung Transplant Recipients	Phase 3
Completed	`NCT00701922` - Surveillance Study of Viral Infections Following Lung Transplantation	N/A
Active, not recruiting	`NCT02936505` - Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD.	N/A