Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described small airway remodelling in these patients.
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay
and matrix remodelling could be responsible for these changes. Using CLME changes of in the
bronchiolar wall and alveolar ducts can be visualized, described and measured.
In lung transplant recipients, CMLE will be performed to distinguish characteristics of
distal airways in stabile patient in contrast to patients with bronchiolitis obliterans
syndrome.
In both groups data will be correlated with CT findings, pulmonary function tests and
anatomopathological results.
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Observational Model: Case Control, Time Perspective: Prospective
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