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Lung Transplantation clinical trials

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NCT ID: NCT02876250 Withdrawn - Clinical trials for Lung Transplantation

Postconditioning by Cyclosporin A in Pulmonary Transplantation

CsA Poumon
Start date: January 2017
Phase: Phase 3
Study type: Interventional

The morbidity and mortality of patients undergoing lung transplantation in the acute phase following surgical intervention is mainly due to the primary graft failure (PGF). The occurrence of PGF is multi factorial but is mainly caused by ischemia-reperfusion injury. The pulmonary graft suffers two periods of ischemia one when it is explanted from the donor (cold ischemia) followed by another when it is grafted into the recipient's thoracic cavity (warm ischemia). The brutal reperfusion of the graft exposes it to reperfusion injury that causes PGF. PGF occurs in up to 20% of transplanted patients and is associated with significantly higher levels of 30-days all-cause mortality. Patients with PGF have a 40% mortality at 30-days versus a 6% mortality in patients without PGF. Ischemic postconditioning, has recently been described in experimental models of ischemia-reperfusion injury in the heart, and although not yet fully understood. Several studies suggest that the mitochondria play a central role in cellular survival mechanisms after a prolonged period of ischemia-reperfusion (with the mitochondrial permeability transition pore (mPTP)). Experimental studies have shown that cyclosporin A (CsA) administered prior to reperfusion binds to cyclophilin D and blocks the opening of mPTP after reperfusion. This protective effect of ischemia-reperfusion injury by CsA has been shown in experimental studies and in clinical phase II trials in reperfused myocardial infarction patients. The hypothesis of this study is that the administration of CsA in transplanted patients (before re-opening of the first pulmonary graft vessels) protects the transplanted lung(s) from the deleterious effects of ischemia-reperfusion injury and thus reduce the frequency and severity of PGF.

NCT ID: NCT02855372 Not yet recruiting - Clinical trials for Lung Transplantation

Impact of the Age Difference Between the Donor and Recipient on the Morbidity and Mortality After Lung Transplantation. Study on a National Multicenter Cohort (COLT)

Start date: October 2016
Phase: N/A
Study type: Observational

It is commonly accepted that the characteristics of the organ donor impact on the future post transplant. In lung transplantation (LP), the defining characteristics of the "ideal" donor includes an age less than 55 years. However, before the pulmonary graft shortage with a corresponding mortality still too high waiting list, the lung graft acceptance criteria were reassessed permitting criteria "extension" ( "marginal" graft). And were grafted, depending on the urgency and accessibility problems in the registry of potential candidate, organs from donors aged 55 and older with quite comparable to those obtained from younger donors . Nevertheless, it is common practice that the grafts from older donors are more readily allocated to older candidates and the most severe, as many confounding factors to assess the real impact of donor age on post-transplant evolution on small cohorts. The main goal of this study is to compare the survival of lung transplant patients depending on the age difference between donor and recipient. The study will be conducted from a broad national cohort of lung transplant patients registered in COLT ( Lung Transplantation COhort). Established in September 2009, promoted by the University Hospital of Nantes, COLT involves 11 lung transplant centers authorized on French territory. It provides a standardized common longitudinal monitoring of the recipient from his transplant. Currently more than 1,000 patients included in this study are transplanted.

NCT ID: NCT02799810 Enrolling by invitation - Clinical trials for Lung Transplantation

Psychosocial Evaluation Prior to Lung Transplantation

EVALUT
Start date: January 2016
Phase: N/A
Study type: Observational [Patient Registry]

In a prospective longitudinal cohort study we aim at investigating the extent to which pre-transplant psychosocial levels of functioning predict the medical and psychosocial outcomes of lung transplantation. There is evidence that e.g. persistently elevated depressive symptoms are associated with reduced survival after lung transplantation

NCT ID: NCT02670239 Recruiting - Clinical trials for Lung Transplantation

Pharmacokinetics of Imipenem During Ex Vivo Lung Perfusion (EVLP)

Start date: May 2014
Phase: N/A
Study type: Observational

Ex vivo lung perfusion (EVLP) is an established strategy to evaluate and optimize high-risk donor lungs that would otherwise be rejected for transplantation mainly due to the presence of edema or infection. Extracorporeal circuits may negatively affects pharmacokinetic (PK) of several drugs including antibiotics, thus exposing patients to risk of therapeutic failure or drug toxicity. The investigators set out to examine the concentration of imipenem in lung perfusate and in lung biopsy during EVLP, and its clinical impact.

NCT ID: NCT02581111 Completed - Clinical trials for Lung Transplantation

Naloxone for Optimizing Hypoxemia Of Lung Donors

NO-HOLDS
Start date: September 2015
Phase: Phase 2/Phase 3
Study type: Interventional

Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals hypoxemia, as defined by the ratio of partial pressure of oxygen in arterial blood (PaO2) to fraction of inspired oxygen (FiO2) below 300 mm Hg, unless they have already been ruled-out for lung recovery. Investigators aim to assess whether naloxone improves oxygenation prior to organ recovery more than placebo.

NCT ID: NCT02265835 Completed - Clinical trials for Lung Transplantation

Anastomotic Airway Complications After Lung Transplantation

Start date: January 2014
Phase: N/A
Study type: Observational

Retrospective analysis of data concerning anastomotic airway complications after lung transplantation.

NCT ID: NCT02237976 Completed - Clinical trials for Lung Transplantation

Self-hypnosis in Patients Awaiting Lung Transplantation

SelfHypTp
Start date: July 31, 2014
Phase: N/A
Study type: Interventional

The proposed study is designed to utilize a self-hypnosis training program for patients awaiting lung transplantation. This technique can increase their well being, particularly by decreasing postoperative pain.

NCT ID: NCT02177916 Recruiting - Clinical trials for Lung Transplantation

Patient Education Study to Determine Knowledge Acquisition in Patients Preparing to Undergo Lung Transplantation

Start date: September 2014
Phase: N/A
Study type: Interventional

The Lung Transplant Team at Tampa General Hospital has identified a need to improve both the quality and quantity of the education that is provided to patients listed for lung transplantation. We propose to change the method and timing of our transplant patient education. The objective of this prospective data collection will be to collect and analyze pre and post test scores of patients when patient education is provided via compact disc as compared to individualized teaching.

NCT ID: NCT01841307 Terminated - Clinical trials for Idiopathic Pulmonary Fibrosis

Cromolyn Detection of Silent Aspiration

Start date: July 2015
Phase: Phase 1
Study type: Interventional

The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract. In the inpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 4 ingestions (at 2h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 5 healthy control subjects and 5 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) with microaspiration. In the outpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 1 ingestions (at 4h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 10 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) with microaspiration.

NCT ID: NCT01729637 Completed - Clinical trials for Lung Transplantation

SI-EVLP Study: STRESS INDEX in Lung Reconditioning

Start date: July 2011
Phase: N/A
Study type: Observational

In order to minimize mechanical stress the investigators propose to implement EVLP procedure with a ventilation monitoring guided by the analysis of the Paw-t shape.