Lung Transplant Rejection Clinical Trial
— OPILOfficial title:
Organizing Pneumonia in Lung Transplant Recipients, a Restrospective Exploratory Study (OPIL-Study)
Verified date | January 2024 |
Source | University of Zurich |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The aim of this study is to generate evidence regarding organizing pneumonia in lung transplant recipients.
Status | Active, not recruiting |
Enrollment | 280 |
Est. completion date | July 2026 |
Est. primary completion date | July 2025 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - All lung transplant recipients treated in the lung transplantation department of the USZ will be included in this analysis with documented tissue sampling or autopsy between 01.01.2012 and 01.06.2023 Exclusion Criteria: - Denied general consent or any statement verbal or in writing by patient that precludes research |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital Zurich | Zurich |
Lead Sponsor | Collaborator |
---|---|
University of Zurich |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of organizing pneumonia | 01.01.2012-01.06.2023 | ||
Secondary | Body Mass Index | date of organizing pneumonia | ||
Secondary | Forced expiratory volume in 1 second | 1 year before and after organizing pneumonia | ||
Secondary | Total lung capacity | 1 year before and after organizing pneumonia | ||
Secondary | Vital capacity | 1 year before and after organizing pneumonia | ||
Secondary | Prevalence of primary graft dysfunction | 01.01.2012-01.06.2023 | ||
Secondary | Cell count of eosinophils in blood | 1 year before and after organizing pneumonia | ||
Secondary | Cell count of lymphocytes in blood | 1 year before and after organizing pneumonia | ||
Secondary | Cell count of neutrophils in blood | 1 year before and after organizing pneumonia | ||
Secondary | Level of rhematoid factor in blood | date of organizing pneumonia | ||
Secondary | Level of anti-nuclear antibodies in blood | date of organizing pneumonia | ||
Secondary | Level of antineutrophil cytoplasmic antibodies in blood | date of organizing pneumonia | ||
Secondary | Prevalence of infection | date of organizing pneumonia | ||
Secondary | C-reactive proteine | date of organizing pneumonia | ||
Secondary | Histopathological patterns beside organising pneumonia | date of organizing pneumonia | ||
Secondary | Radiological findings in CT scan | date of organizing pneumonia | ||
Secondary | Medication associated with organizing pneumonia | date of organizing pneumonia | ||
Secondary | NTproBNP | date of organizing pneumonia | ||
Secondary | Echocardiography | 1 year before and after organizing pneumonia | ||
Secondary | Cellcount in the bronchoalveolar lavage | 1 year before and after organizing pneumonia | ||
Secondary | Level of donor specific antibodies | 1 year before and after organizing pneumonia | ||
Secondary | Time to death | after diagnosis of organizing pneumonia | ||
Secondary | Reason for death according to biopsy results od physician declared cause of death | after diagnosis of organizing pneumonia (- 01.06.2023) | ||
Secondary | Number of patients with therapeutic interventions due to organizing pneumonia | 01.01.2012-01.06.2023 | ||
Secondary | Prevalence of risk factors of OP | Prevalence of infection (Virus/Bacteria/Fungus)
CMV/EBV PCR results Graft ischemic time Prevalence and type of malignant diseases (eg PTLD) Rheumatic disease (Connective tissue disease, vasculitis) GERD with aspiration (upper endoscopy findings or pH-metric findings) Common variable immunodeficiency Inflammatory bowel syndrome Medication or monitoring non-compliance Radiation Malignant disease |
01.01.2012-01.06.2023 |
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