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RENAL: TNF-alpha Inhibitor for Improving Renal Dysfunction and Primary Graft Dysfunction After Lung Transplant

Lung Transplant; Complications Clinical Trial

Official title:
RENAL: Randomized Clinical Trial of TNF-alpha Inhibitor for Improving Renal Dysfunction and Primary Graft Dysfunction After Lung Transplant

Clinical Trial Summary

The purpose of this study is to assess whether TNFa antibody use before lung transplant can prevent kidney injury after lung transplant.

Clinical Trial Description

After being informed about the study and potential risks, all patients giving written consent who undergo a lung transplant will be randomized in a 1:1 ratio to either the treatment or control group. Patients randomized to the treatment group will receive one dose of the study drug, Etanercept, via subcutaneous injection just prior to the lung transplant. Patients randomized to the control group will not receive Etanercept. Both groups will receive standard lung transplant care after implantation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05950724
Study type Interventional
Source Northwestern University
Contact
Status Enrolling by invitation
Phase Early Phase 1
Start date September 17, 2023
Completion date April 2025
View Details
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