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Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated NSCLC Patients

Lung Neoplasms Clinical Trial

Official title:
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy of NSCLC Patients Treated With Immune Checkpoint Inhibitors (ICIs) or Targeted Therapy

Clinical Trial Summary

To evaluate the predictive value of ctDNA in response, relapse for patients treated with immune checkpoint inhibitors or targeted therapy for ALK, ROS1, MET ex14 skipping.

Clinical Trial Description

In the study, 250 advanced NSCLC patients will be recruited. All the patients will receive tissue biopsy and circultating tumor DNA (ctDNA) liquid biopsy before entry the study. Patients who have no actionable mutations in EGFR or ALK and receive ICIs treatment and patients who carry actionable ROS1 fusion, ALK fusion or MET exon 14 skipping mutation and receive TKI treatment according to guidelines will take liquid biopsy assay to monitor the mutation status. The study will be ended when over 70% of the patients had a progressive disease (PD) in their targeted lesion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04566432
Study type Observational
Source Geneplus-Beijing Co. Ltd.
Contact Rongrong Chen, MD, PhD
Phone 86-10-53955678
Email chenrr@geneplus.org.cn
Status Recruiting
Phase
Start date July 1, 2020
Completion date June 30, 2024
View Details
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