Lung Neoplasms Clinical Trial
Official title:
Does Intense Regimented Surveillance Improve the Rates of Therapeutic Re-Intervention After Lung Cancer Surgery: A Pilot Study for the Intense-CT Trial
After curative lung cancer surgery, there is a risk of recurrence of the primary cancer, or
development of a new cancer. Historically, patients who have undergone curative lung cancer
surgery have been monitored with chest radiographs (CXR). Unfortunately, 70% of such patients
still die of lung cancer. As a result, there has been interest in other methods of
surveillance in order to detect recurring or new cancers earlier and have more success in
treating them. One such technique is Low Dose Computed Tomography (LDCT), which is currently
the standard of care and surveillance at this institution. This pilot study aims to determine
whether regimented, intensive, short interval LDCT surveillance leads to higher rates of
detection and treatment of recurring lung cancers. The study group will be followed up
according to a regimented surveillance program using LDCT. The study group will be compared
to a group of historical controls whose follow up after surgery was not standardized, but
rather left up to the discretion of the individual surgeon. If the results of this study show
improvements in detection and treatment of recurrent cancers, it will allow for a larger
trial to study the effects of the LDCT surveillance program on lung cancer survival.
The study question aims to determine whether for survivors after curative surgery for Stage I
and Stage II lung cancer, a structured Surveillance Program with Low Dose CT can increase the
rate of detection and treatment of recurring or new cancers when compared to historical
non-structured surveillance with CXR. This study will also determine if it is warranted to
pursue a larger scale randomized controlled trial to further investigate optimal LDCT
surveillance follow-up intervals and long-term lung cancer survival.
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