Cystic Fibrosis Clinical Trial
Official title:
Pilot Observational Study to Determine Feasibility of a Standardized Treatment of Pulmonary Exacerbations in Patients With Cystic Fibrosis
The goal of this research study is to better understand current treatment practices for pulmonary exacerbations (lung infections) and whether the Cystic Fibrosis National Patient Registry (CFFNPR)can be used for this type of study.
Cystic fibrosis (CF), a life-shortening genetic disease, is marked by acute episodes during
which symptoms of lung infection increase and lung function decreases. These pulmonary
exacerbations (PEs) are treated with varying antibiotics for varying time periods based on
needs determined by individual patients, their families, and the health care providers.
Cystic fibrosis pulmonary guidelines for the treatment of PE published by the Cystic
Fibrosis Foundation (CFF) in 2009 provided recommendations for treatment and also identified
key questions for which additional studies were needed.
Standard treatment for PE involves many facets including selection of antibiotics, duration
of use, and outcomes that define treatment success. Understanding current treatment
practices and measures of treatment success are needed before a study can be designed to
define optimal treatment strategies.
This is a multi-center, prospective, observational study designed to prospectively follow
patients with CF that are initially admitted to the hospital for treatment of a pulmonary
exacerbation.
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Observational Model: Cohort, Time Perspective: Prospective
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