Electronic Cigarette Use Clinical Trial
Official title:
Acute Health Effects of Passive Exposure to Particles From Electronic Cigarettes - a Randomized Controlled Double-blinded Cross-over Trial Among COPD Patients
The use of e-cigarettes is often permitted in otherwise smoke-free areas causing passive vape
exposure for present individuals. Little is known about the potential adverse health effects
of passive vape, and people with respiratory diseases may be more susceptible.
The aim of the present study was to investigate local and systemic effects of short-term
passive exposure to vape from e-cigarettes among patients with mild or moderate chronic
obstructive pulmonary disease COPD in a randomized controlled double-blinded cross-over
study.
Introduction: The use of e-cigarettes is often permitted in otherwise smoke-free areas
causing passive vape exposure for present individuals. Little is known about the potential
adverse health effects of passive vape, and people with respiratory diseases may be more
susceptible.
Aim: to investigate local and systemic effects of short-term passive exposure to vape from
e-cigarettes among patients with mild or moderate chronic obstructive pulmonary disease
(COPD).
Design: In a randomised double-blinded cross-over study non-smoking COPD patients were
exposed for four hours at two different exposure conditions separated by 14 days; A) clean
filtered air and B) passive vaping under controlled environmental conditions.
Measurements: TSI P-TRAK Ultrafine Particle Counter was used for particle counts. Health
effects, including lung function (FEV1/FVC) and fraction of exhaled nitric oxide (FeNO) were
evaluated in relation to local and systemic effects prior to, right after and 24 h. after
exposure.
Analysis: Mixed methods approach taking both time and exposure into account.
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