Lung Function Clinical Trial
Official title:
Maximal Effort-dependent Respiratory Flow Rates: Reproducibility and Reference Values
The general objective of this project is to determine the best method to measure maximal inspiratory flow rates, to study their reproducibility and create reference equations in healthy subjects.
1. Reproducibility and reference values in normal subjects: the investigators will propose
a method for measurement of the maximal inspiratory flow rates (MIFR) and establish
their reproducibility in normal subjects. The variability of these inspiratory flow
rates will be compared with the variability of effort dependent and non-effort dependent
expiratory flow rates.
Also, reference equations will be drawn up and compared to the only existing set of
reference values (2) (needing a revision).
2. Reproducibility in disease: the investigators will evaluate the reproducibility of the
MIFR in patients with neuromuscular diseases (Steinert muscular dystrophy, amyotrophic
lateral sclerosis) and with upper airway obstruction (tracheal stenosis, thyroid
enlargement) and compare to the reproducibility of expiratory flow rates in this
population.
3. Monitoring of diseases: In the neuromuscular patients MIFR will be correlated to the
existing parameters used for monitoring of these diseases (respiratory muscle strength,
forced vital capacity), with a longitudinal follow-up.
In the patients with upper airway obstruction the MIFR (quantitative measurement) will be
compared to the visual inspection (qualitative interpretation) of the maximal flow-volume
loop and also the evolution after a therapeutic intervention (airway stenting, thyroidectomy)
will be monitored.
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