Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Lung Disorder Clinical Trial

Official title:

Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05720845
• Other study ID #: 20230111
• Status: Not yet recruiting
• Phase: N/A
• Start date: February 8, 2023
• Est. completion date: March 18, 2025

Study information

• Verified date: January 2023
• Source: Guangzhou Institute of Respiratory Disease
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing interventional pulmonology procedures under general anesthesia. Ventilatory strategy to prevent reduce the intra-procedural development of atelectasis during interventional pulmonology procedures under general anesthesia.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 60
• Est. completion date: March 18, 2025
• Est. primary completion date: January 18, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Adult patients undergoing interventional pulmonology procedures with radial probe endobronchial ultrasound (RP-EBUS) for peripheral lung lesions

• Recent (< 4 weeks) chest computed tomography (CT) performed prior to the bronchoscopy

Exclusion Criteria:

• Patients with baseline lung consolidation, interstitial changes or lung masses (> 3 cm in diameter) in dependent areas of the lung (right/left [R/L] B6, 9, or 10 bronchial segments) as seen on most recent CT

• History of primary or secondary spontaneous pneumothorax

Related Conditions & MeSH terms

• Lung Disorder
• Pulmonary Atelectasis

Intervention

Procedure:
• VESPA
Using Ventilatory strategy of prevent atelectasis for General Anesthesia.
• conventional mechanical ventilation
Conventional mechanical ventilation for General Anesthesia.

Locations

Country	Name	City	State
China	Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou Institute of Respiratory Disease

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Presence or absence of new atelectasis for each segment	The proportion of patients identified as developing intraprocedural atelectasis by radial probe endobronchial ultrasound (RP-EBUS)	During bronchoscopy, an average of 1 hour.
Secondary	Ventilation-induced complications		Within 48 hours of bronchoscopy
Secondary	Bronchoscopy-induced complications		Within 48 hours of bronchoscopy
Secondary	Assess the regional ventilation distribution by Electrical impedance tomography (EIT)		During bronchoscopy, an average of 1 hour.