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Vitamin D Deficiency and Effect of Its Supplementation on Interstitial Lung Diseases(ILD). — ILD  

Vitamin D Deficiency Clinical Trial

Official title:
Vitamin D Deficiency in Interstitial Lung Diseases

Clinical Trial Summary

This study evaluates serum level of Vitamin D in Interstitial Lung Diseases in patients with Interstitial Lung Diseases other than connective tissue diseases associated-Interstitial Lung Diseases and effects of its supplementation.

All patients will receive the standard regimen of treatment (corticosteroids and immunosuppressive drugs)and will be randomly assigned to either Group 1:who will receive Vitamin D supplementation (Interventional group)or Group 2:who will not receive Vitamin D supplementation(Control group).

Clinical Trial Description

Pulmonary fibrosis was due to chronic inflammation and disordered wound healing in response to damage induced by a variety of agents such as viral infection and radiotherapy or environmental toxins.it is characterized by accumulation of myofibroblasts and excessive deposition of the extracellular matrix.Epithelial cells undergoes epithelial mesenchymal transition (EMT).

Supplementation with vitamin D or its analogs suppresses lung fibrosis via triggering anti-fibrotic effect through attenuation of transforming growth factor beta (TGF-B).vitamin D can reduce TGF-B expression and attenuate TGF-B induced epithelial mesenchymal transition in lung fibroblast and epithelial cells. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04100226
Study type Interventional
Source Cairo University
Contact
Status Active, not recruiting
Phase N/A
Start date March 1, 2019
Completion date January 1, 2020
View Details
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