Fluid Biopsy for the Diagnosis of Lung Cancer

Status Recruiting

Clinical Trial Summary

This trial collects and studies blood samples via fluid biopsy for the diagnosis of lung cancer. Studying blood samples in the laboratory may help doctors develop a blood test for lung cancer in the future and provide a better way to screen patients for lung cancer.

Clinical Trial Description

PRIMARY OBJECTIVE: I. To estimate the sensitivity and specificity of the fluid biopsy in establishing a diagnosis of bronchogenic carcinoma. SECONDARY OBJECTIVES: I. To determine the accuracy of determination of the histologic subtype of bronchogenic lung cancer. II. To determine the relative contribution of cell based high definition circulating tumor cell assay (HD-CTC) and imaging mass cytometry (IMC) and plasma based circulating tumor deoxyribonucleic acid (ctDNA) assays in determination of diagnosis and histologic subtype. OUTLINE: Patients undergo collection of blood samples on day 1 for analysis via high definition (HD)-single cell analysis (SCA) fluid biopsy. Medical charts of patients are reviewed at 3 months post-biopsy or computed tomography (CT) screening. After completion of study, patients are followed for up to 1 year. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04162678
Study type	Observational
Source	University of Southern California
Contact	Sandy Tran, RN
Phone	323-865-0451
Email	Sandy.Tran@med.usc.edu
Status	Recruiting
Phase
Start date	January 13, 2020
Completion date	January 13, 2026

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04931017` - Metformin for Chemoprevention of Lung Cancer in Overweight or Obese Individuals at High Risk for Lung Cancer	Phase 2
Recruiting	`NCT05898594` - Lung Cancer Screening in High-risk Black Women	N/A
Not yet recruiting	`NCT06038526` - Evaluation of Canakinumab in High-Risk Former-Smokers	Phase 2
Terminated	`NCT02856581` - Management of Tobacco Treatment Intervention in Reducing Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes	Phase 3
Completed	`NCT04922697` - Educational Intervention for the Promotion of Knowledge and Preventive Health Behaviors Related to Personal Air Pollution Exposure, The Air Study	N/A
Recruiting	`NCT04644952` - The Rise in Robotic Atypical Segmentectomies
Completed	`NCT01896778` - Body Warming in Improving Blood Flow and Oxygen Delivery to Tumors in Patients With Cancer	N/A
Recruiting	`NCT05407168` - Improving Decision-Making Encounters in Lung Cancer Using a Low-Literacy Conversation Tool	N/A
Completed	`NCT04267874` - Black Raspberry Nectar for the Prevention of Lung Cancer, BE WELL Study	Early Phase 1
Recruiting	`NCT02408861` - Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery	Phase 1
Recruiting	`NCT03709953` - Efficacy and Safety of Apatinib as Third-line Therapy for Primary Pulmonary Lymphoepithelioid Carcinoma	Phase 2
Active, not recruiting	`NCT03267524` - Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal Cancer and Their Family Caregivers	N/A
Recruiting	`NCT04147494` - Experimental PET Imaging Scans Before Cancer Surgery to Study the Amount of PET Tracer Accumulated in Normal and Cancer Tissues	Early Phase 1
Completed	`NCT02237183` - Iloprost in Preventing Lung Cancer in Former Smokers	Phase 1
Recruiting	`NCT04783168` - Walking After Surgery to Improve Recovery and Outcomes After Surgery, AIRTECH Study	N/A
Completed	`NCT04635761` - Awareness, Information, and Resources for Lung Cancer Screening Program for Community-Partnered Lung Cancer Screening	N/A
Recruiting	`NCT06445192` - Evaluating the Impact of a Virtually Supervised Exercise Intervention and Group Counseling on Inflammation and the Microbiome of Smokers at High Risk for Lung Cancer, BE FIT Trial	N/A
Active, not recruiting	`NCT03164486` - First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide	Early Phase 1
Recruiting	`NCT05802186` - Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study	N/A
Active, not recruiting	`NCT01696968` - Screening for Lung Cancer in Older Patients (PLCO Screening Trial)	N/A