Clinical Trials Logo

Clinical Trial Summary

Lung cancer remains one of the most commonly diagnosed oncological diseases worldwide and the first in terms of mortality. Although immune checkpoint inhibitors form the backbone of current metastatic non-small cell lung cancer treatments, there is still no ideal predictive marker for its efficacy and patients still achieve suboptimal results in overall response and survival. While immune checkpoint inhibitors are known to shift systemic anti-tumor immune response from suppression to stimulation in some patients, the investigators hypothesize that this effect can be further enhanced by cryotherapy, especially in "cold" tumors. If proven successful, cryotherapy in combination with immunotherapy, could potentiate a more powerful immune response compared to systemic therapy alone, improve overall response rate, patients' survival without disease progression, and overall survival. The investigators, therefore, aim to use combined local tumor cryotherapy, combined with immune checkpoint inhibitor therapy to induce and evaluate systemic anti-tumor T lymphocyte response and achieve improved non-small cell lung cancer patient outcomes than with immunotherapy alone.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06000358
Study type Interventional
Source Lithuanian University of Health Sciences
Contact Marius Zemaitis, PhD, professor
Phone +37061256473
Email marius.zemaitis@kaunoklinikos.lt
Status Recruiting
Phase N/A
Start date April 1, 2023
Completion date March 31, 2026

See also
  Status Clinical Trial Phase
Active, not recruiting NCT03668496 - A Study of SHR-1210 in Combination With Carboplatin + Paclitaxel in Subjects With Squamous NSCLC Phase 3
Active, not recruiting NCT03322072 - Calypso Guided High Precision Stereotactic Ablative Radiosurgery for Lung TUmours Using Real-Time Tumour Tracking & Respiratory Gating N/A
Recruiting NCT05497973 - Psychosocial eHealth in Advanced Lung Cancer N/A
Recruiting NCT06076005 - Lung Cancer ID (Identity) Study
Recruiting NCT05860296 - Testing Experimental Anti-cancer Drug SLC-391 With an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers Phase 1/Phase 2
Recruiting NCT05311709 - Sotorasib in Advanced KRASG12C-mutated Non-small Cell Lung Cancer Patients With Comorbidities Phase 2
Completed NCT04825912 - Resilience Measurement in Older Adults With Late-Stage Lung Cancer N/A
Completed NCT03529851 - Feasibility of a Web-based Patient Reported Outcome Symptom Monitoring Application in Danish Lung Cancer Patients N/A
Completed NCT03558165 - Lung Cancer Next Generation Sequencing Using the Oncomine Comprehensive Assay
Completed NCT03076164 - A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib Phase 1/Phase 2
Not yet recruiting NCT03153358 - Icotinib Combined With SBRT for Patients With Metastatic Non-squamous NSCLC With EGFR Mutation Phase 2
Recruiting NCT04595734 - Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.
Recruiting NCT04519983 - Efficacy of SRT as Salvage Therapy in Patients With Brain Oligo-progression of EGFR-mutant Non-small Cell Lung Cancer After Failure of the Third-generation EGFR-TKIs Phase 2
Not yet recruiting NCT05701384 - Lazertinib 160mg in EGFR T790M NSCLC Phase 2
Withdrawn NCT03409341 - Personalizing Immune Checkpoint Inhibitor Therapy
Active, not recruiting NCT03728361 - Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Phase 2
Not yet recruiting NCT06024941 - Re-induction of a Systemic Immune Response in Metastatic or Locally Recurrent Lung Cancer Phase 2
Recruiting NCT04669223 - Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion N/A
Recruiting NCT05996263 - Prognostic Value of Combined Approach Based on KEAP1/NFE2L2 Mutations and Pre-therapeutic FDG-PET/CT Radiomic Analysis in Advanced Non-small-cell Lung Cancer PDL1 ≥ 50% Treated With Pembrolizumab (PEMBROMIC)
Completed NCT04057196 - Self-System Therapy for Older Adults With Lung Cancer N/A