Lumbar Surgery Clinical Trial
Official title:
Assessment of the Nociception During Lumbar Surgery
The aim of the study is to assess the accuracy of a new paradigm in measuring the level of nociception during lumbar surgery. The paradigm is based the measurement of the baroreflex in response to noxious stimuli in anesthetized patients.
The study aims at exploring the changes in the baroreflex induced by 3 noxious stimulation
in anesthetized patients: tracheal intubation, tetanic stimulus, and surgical incision.
Patients are randomly assigned to one of 2 groups: remifentanil-2 or remifentanil-4,
corresponding to the target effect site concentration of this drug delivered through a TCI
system. Other drugs included propofol and cisatracurium.
The paradigm exploring the baroreflex collects information continuously recorded of the RR
intervals and the changes in systolic arterial pressure, before and during noxious stimuli.
The hypothesis is that this paradigm explores nociception as the group with smaller doses in
remifentanil will have more cardiovascular reactions in response to noxious stimuli.
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Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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