Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery

Lumbar Spinal Stenosis Clinical Trial

Official title:

Randomized Controlled Study of Fever Probability, Risk Factors and Preventive Use of Non-steroidal Anti-inflammatory Drugs on Fever After Removal of Drainage Tube After Lumbar Fusion

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04042948
• Other study ID #: IRB00006761-M2019299
• Status: Completed
• Phase: N/A
• Start date: June 24, 2019
• Est. completion date: December 30, 2019

Study information

• Verified date: June 2021
• Source: Peking University Third Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the influence of Non-steroidal Anti-inflammatory Drugs on preventing fever after the removal of drainage tube in the patients who suffered lumbar fusion surgery, if the outcome turn out positive, the preventive use of non-steroidal anti-inflammatory drugs could decrease the possibility of fever happening when we remove the tube.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 183
• Est. completion date: December 30, 2019
• Est. primary completion date: November 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• adult patient

• diagnosis of lumbar spinal stenosis

• perform decompression and fusion surgery and lay a drainage tube

• understand the test and could sign the name

Exclusion Criteria:

• beside the inclusion criteria

Related Conditions & MeSH terms

• Fever
• Lumbar Disc Herniation
• Lumbar Radiculopathy
• Lumbar Spinal Stenosis
• Radiculopathy
• Spinal Stenosis

Intervention

Drug:
• Tylenol
when we decide to remove the drainage tube, we ask the patient to take a pill of tylenol, and another pill in 12h later

Locations

Country	Name	City	State
China	Peking University Third Hospital	Beijing	Haidian

Sponsors (1)

Lead Sponsor	Collaborator
Peking University Third Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the rate of fever after the removal of drainage tube	we test the temperature of the patient in 24h after the removal of tube, we define fever if the temperature is higher than 37.8 degree	24 hours
Secondary	the level of WBC	we compare the change of the level of WBC of two groups in 24h after the removal of the drainage tube	24 hours
Secondary	the level of CRP	we compare the change of the level of CRP of two groups in 24h after the removal of the drainage tube	24 hours
Secondary	the level of ESR	we compare the change of the level of ESR of two groups in 24h after the removal of the drainage tube	24 hours
Secondary	the temperature	we compare the change of the level of temperature of two groups in 24h after the removal of the drainage tube	24 hours