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Lumbar Disc Herniation clinical trials

View clinical trials related to Lumbar Disc Herniation.

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NCT ID: NCT03060434 Active, not recruiting - Clinical trials for Lumbar Disc Herniation

Pentoxifylline and Lumbar Radiculopathy

Start date: June 1, 2018
Phase: Phase 4
Study type: Interventional

The objective of this prospective controlled crossover study is to evaluate the efficacy and safety of pentoxifylline per os (800 mg daily) in the management of lumbar radiculopathy

NCT ID: NCT02525120 Active, not recruiting - Clinical trials for Lumbar Disc Herniation

Post Market Non-Inferiority Study Comparing Triojection® to Discectomy for Lumbar Disc Herniation

Start date: July 2015
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to compare the early clinical outcomes following non-surgical treatment with Triojection® to surgical discectomy. Early is defined as less than or equal to 6 months.

NCT ID: NCT02372032 Active, not recruiting - Clinical trials for Lumbar Disc Herniation

A Trial of Percutaneous Lumbar Discectomy Combined With Ozone for Treatment of LDH

Start date: February 2015
Phase: Phase 3
Study type: Interventional

Lumbar disc herniation (LDH) is a common pathological process leading to spinal surgery. Open discectomy used to be a widespread procedure for surgical treatment for symptomatic LDH. Currently, several minimal invasive surgeries have been uesd widely. Percutaneous lumbar discectomy(PLD) and ozone therapy are two widely used minimal invasive treatment, and ozone therapy combined other minimally invasive treatment could improve other minimally invasive treatment's clinical effectiveness. The effectiveness of which has been proved to be comparable to conventional open discectomy. In this study, a single-blind randomized controlled trial will be performed to evaluate the effectiveness of two minimal invasive discectomy, percutaneous lumbar discectomy combined with ozone and percutaneous lumbar discectomy, for the treatment of symptomatic LDH. Two groups of patients will be investigated; 1) patients diagnosed with lumbar disc herniation undergoing PLD combined with ozone, and 2) patients diagnosed with lumbar disc herniation undergoing PLD. The primary endpoints of the study will be changes in in pain and functional status by the Visual Analog Scale (VAS) and functional status as measured by Oswestry Low Back Disability Questionnaire (Oswestry Disability Index,ODI) and Japanese Orthopaedic Association (JOA) as measured at pre- and post-operation, 1 month, 3 months, 6 months. Secondary outcomes include response evaluation by MacNab response evaluation criteria as measured at pre- and post-operation, 1 month, 3 months, 6 months. Treatment effect is defined as the difference in the mean change from baseline between the two groups. For the first time,the results of this trial will provide scientific evidence as to the relative effectiveness of PLD combined with ozone versus PLD for minimal invasive surgical treatment for symptomatic lumbar disc herniation.

NCT ID: NCT01552486 Active, not recruiting - Clinical trials for Lumbar Disc Herniation

Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation

Start date: June 2012
Phase: N/A
Study type: Interventional

Comparisons of surgical and non-operative treatment of patients with acute sciatica secondary to lumbar intervertebral disc herniation (AS/LDH) have shown no appreciable difference in outcome. The composition of the non-operative treatment of this patient population remains poorly defined. Spinal manipulative therapy (SMT) has demonstrated value in the treatment of AS/LDH. Recent preliminary studies suggest that SMT provides therapeutic benefit through the modulation of in vivo inflammatory mediators. This feasibility study will define the key experimental variables required to conduct a large multicentre study that will clarify the biological and clinical outcomes of SMT in the treatment of patients with AS/LDH.

NCT ID: NCT01283438 Active, not recruiting - Clinical trials for Lumbar Disc Herniation

A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation

Start date: December 17, 2010
Phase: Phase 4
Study type: Interventional

A randomized study to demonstrate the superiority of the Barricaid® when used in conjunction with limited discectomy, compared to limited discectomy alone, with regard to preventing reherniation and the recurrence of pain or dysfunction.

NCT ID: NCT01236924 Active, not recruiting - Clinical trials for Lumbar Disc Herniation.

Effectiveness of Global Postural Reeducation in Patients With Chronic Symptomatic Lumbar Disc Herniation

Start date: January 2011
Phase: Phase 1
Study type: Interventional

Slipped disc is the rupture of the fibrous ring, with subsequent displacement of the nucleus pulposus in intervertebral spaces, which may cause compression of nerve structures. It is estimated that 2-3% of the population have taken with this process, whose prevalence is 4.8% in men and 2.5% in women over 35 years. Thus, the purpose of this study is to verify the effectiveness of global postural reeducation in patients diagnosed with chronic symptomatic lumbar disc herniation with the application of a randomized controlled trial. Will be measured pain, disability and functional flexibility.