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Lower Respiratory Tract Illness clinical trials

View clinical trials related to Lower Respiratory Tract Illness.

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NCT ID: NCT05035212 Recruiting - Clinical trials for Lower Respiratory Tract Illness

Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.

RENOIR
Start date: August 31, 2021
Phase: Phase 3
Study type: Interventional

Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a single dose of RSVpreF in the prevention of LRTI-RSV in adults: - At a dose of 120µg. - In adults 60 years of age and older. - The duration of the study for each participant will be up to approximately 24 months. - The study will be conducted in the United States, Canada, Netherlands, Finland, Argentina, Japan and South Africa. Substudy A: This study is an extension of the efficacy study and was designed to evaluate the safety and immunogenicity of a second dose of RSVpreF when administered after a dosing interval of approximately 2 years: - At a dose of 120µg (as studied in the Phase 3 Efficacy Study) - Blood samples will be collected for antibody testing. - The duration of the study for each participant will be up to approximately 18 months. - The study will be conducted in the United States and Argentina. Substudy B: This study was designed to evaluate the safety and immunogenicity of a second dose of RSVpreF when administered after a dosing interval of approximately 1 year: - At a dose of 120µg (as studied in the Phase 3 Efficacy Study) - Blood samples will be collected for antibody testing. - The duration of the study for each participant will be up to approximately 18 months. - The study will be conducted in Argentina.

NCT ID: NCT03756753 Completed - Clinical trials for Acute Respiratory Infection

The RAPID Trial: Assessing Point-of-care Influenza and Other Respiratory Virus Diagnostics

RAPID
Start date: January 3, 2019
Phase: N/A
Study type: Interventional

The RAPID trial is a randomized controlled trial that looks at the clinical impact of a rapid respiratory test in a pediatric emergency department. Participants will be randomized to the intervention group - results available to medical providers, or the control group- results not available to medical providers.