Low Grade Gliomas Clinical Trial
Official title:
Late Effects of Proton Radiation Therapy in Patients With Low-Grade Glioma
Verified date | January 2017 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Interventional |
In this research study, we are looking to study the side effects from the use of proton radiation in treating people with low-grade gliomas that are recommended radiation treatment. We expect response of the tumors to be the same with proton radiation as compared to standard 3D conformal radiation therapy, but also expect less side effects from radiation.
Status | Completed |
Enrollment | 20 |
Est. completion date | August 2015 |
Est. primary completion date | August 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Histologically confirmed low-grade gliomas, WHO classification II/IV or equivalent low grade histology, including protoplasmic, fibrillary, gemistocytic astrocytomas, and mixed variants such as oligoastrocytomas - Must have at least one of: (1) progressive or recurrent disease as defined by imaging, (2) persistence or progression of debilitating neurological symptoms, or (3) at risk of early progression as defined by either (a) age of 40 or older or (b) MIB-1 of 3% or greater - KPS of 70 or greater - 18 years of age or older - Surgical and medical/chemotherapeutic interventions are per physician's discretion and are acceptable - Must be able to speak and comprehend English Exclusion Criteria: - Other baseline neurocognitive or emotional disorders or deficits, including but not limited to head injury, CVA, TIA, or other cerebral insults with residual neuropsychiatric deficits, psychiatric disorders, learning disabilities, HIV positivity or other medical conditions at high risk of causing neurocognitive decline or emotional instability - Prior history of cranial irradiation - Pregnancy at the time of radiation treatment - Unable to undergo MRI scans (e.g., embedded ferromagnetic metal or pacemakers) - Comorbid illness or reason to suggest a life expectancy of less than 5 years |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Participants With Late Effects > 3 Months Post RT | 5 years | Yes | |
Secondary | Percentage of Participants With Progression Free Survival | Clinical and/or radiographic assessments Percentages were estimated by Kaplan Meier | At 1, 3, and 5 years | No |
Secondary | Percentage of Participants With Overall Survival | Percentages were estimated by Kaplan Meier | At 1, 3, and 5 years | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT00517959 -
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
|
Phase 3 |