Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00681473
Other study ID # 06-195
Secondary ID
Status Completed
Phase N/A
First received May 19, 2008
Last updated January 6, 2017
Start date July 2007
Est. completion date August 2015

Study information

Verified date January 2017
Source Massachusetts General Hospital
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

In this research study, we are looking to study the side effects from the use of proton radiation in treating people with low-grade gliomas that are recommended radiation treatment. We expect response of the tumors to be the same with proton radiation as compared to standard 3D conformal radiation therapy, but also expect less side effects from radiation.


Description:

- Participants will receive radiation therapy for 6 weeks, given in daily doses, Monday through Friday, for a total of 30 treatments.

- A medical history and physical examination will be performed prior to the start of radiation treatment, weekly during the 6 weeks of radiation and after the finish of radiation performed at 3 and 6 months and then annually for 5 years.

- Hormonal function tests will be taken prior to the start of radiation treatment and after the finish of radiation treatment at 3 and 6 months, and annually for five years to assess the participants hormonal functions as they relate to the pituitary gland's function.

- A brain MRI will be performed prior to the start of radiation treatment and then performed at 3 and 6 months after radiation treatment then annually for 5 years.

- A neurocognitive exam will be performed prior to the start of radiation therapy, a limited exam 6 months after the completion of radiation therapy, and a complete exam annually for 5 years.

- Quality of Life and Emotional Well-Being Questionnaires will be done before radiation begins, 2 months after radiation treatment, 6 months after radiation treatment and then annually for 5 years.


Recruitment information / eligibility

Status Completed
Enrollment 20
Est. completion date August 2015
Est. primary completion date August 2015
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Histologically confirmed low-grade gliomas, WHO classification II/IV or equivalent low grade histology, including protoplasmic, fibrillary, gemistocytic astrocytomas, and mixed variants such as oligoastrocytomas

- Must have at least one of: (1) progressive or recurrent disease as defined by imaging, (2) persistence or progression of debilitating neurological symptoms, or (3) at risk of early progression as defined by either (a) age of 40 or older or (b) MIB-1 of 3% or greater

- KPS of 70 or greater

- 18 years of age or older

- Surgical and medical/chemotherapeutic interventions are per physician's discretion and are acceptable

- Must be able to speak and comprehend English

Exclusion Criteria:

- Other baseline neurocognitive or emotional disorders or deficits, including but not limited to head injury, CVA, TIA, or other cerebral insults with residual neuropsychiatric deficits, psychiatric disorders, learning disabilities, HIV positivity or other medical conditions at high risk of causing neurocognitive decline or emotional instability

- Prior history of cranial irradiation

- Pregnancy at the time of radiation treatment

- Unable to undergo MRI scans (e.g., embedded ferromagnetic metal or pacemakers)

- Comorbid illness or reason to suggest a life expectancy of less than 5 years

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Related Conditions & MeSH terms


Intervention

Radiation:
Proton Radiation Therapy
Once daily, Monday through Friday, for 6 weeks.

Locations

Country Name City State
United States Massachusetts General Hospital Boston Massachusetts

Sponsors (2)

Lead Sponsor Collaborator
Massachusetts General Hospital National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Number of Participants With Late Effects > 3 Months Post RT 5 years Yes
Secondary Percentage of Participants With Progression Free Survival Clinical and/or radiographic assessments Percentages were estimated by Kaplan Meier At 1, 3, and 5 years No
Secondary Percentage of Participants With Overall Survival Percentages were estimated by Kaplan Meier At 1, 3, and 5 years No
See also
  Status Clinical Trial Phase
Active, not recruiting NCT00517959 - SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Phase 3