Low Back Pain Clinical Trial
Official title:
Effects of Yoga Versus Passive Modality on Pain, Disability, Salivary Cortisol Concentrations, Brain- Derived Neurotropic Factor, Heart Rate Variability and Immune Functions Among Patients With Chronic Low Back Pain: A Randomized Controlled Trial
This study may clarify a potential promising mechanism and clearest evidence to support the value of yoga as a therapeutic option for reducing chronic low back pain.
Low back pain is a common problem, with 70-80% of adults were bothered in their lives, which
influence the work and quality of life. Yoga is one of the most popular complementary and
alternative medicine for back pain, and this mind-body intervention has increasingly chosen
to effectively treat chronic pain.
This is a parallel-arm randomized controlled trial which will compare the outcomes of
participants assigned to the experimental treatment group (yoga, with 36 participants) with
those assigned to a passive modality control group for 3 months (12 weeks). Each group will
receive regular 60-minutes yoga classes or passive modality twice a week. The investigators
confer the difference of pain relief and functional life improvement between passive
modality and yoga. The latter is expected to have positive effects on Chronic low back pain.
The effects and possible mechanisms of action responsible for passive modality and yoga on
salivary cortisol concentrations, inflammatory cytokines and autonomic nervous tone will be
also evaluated. The study's primary endpoints are (1) back pain relief, (2) functional life
improved, (3) Salivary cortisol concentrations decreased, (4) brain-derived neurotrophic
factor improved, (5) heart rate variability improved, and (6) immune function improved
significantly among the participants in the experimental group than the control group.
This study may clarify a potential promising mechanism and clearest evidence to support the
value of yoga as a therapeutic option for reducing chronic low back pain. If the results are
positive, clinicians will attain more options for treating patient with chronic low back.
Furthermore, the positive results from this study will help focus more future in-depth
research on the most promising potential mechanism of action identifies.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)
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