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Lordosis clinical trials

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NCT ID: NCT04174144 Completed - Spinal Fusion Clinical Trials

The Effect of Lordosis on Clinical Outcome After Spinal Fusion for One-level Degenerative Spondylolysthesis

Start date: December 12, 2019
Phase:
Study type: Observational

Degenerative spondylolisthesis is a common spinal degenerative disease. It is defined as the slippage of one vertebrae on the vertebrae bellow. In the process of spinal ageing and spinal joint degeneration, the spine becomes subjected to degenerative development that results in joint instability, shifting of vertebrae and can be responsible for a progressive kyphosis of the lumbar spine and sagittal imbalance with forward inclination of the trunk and chronic low back pain development. To address these changes and restore stability, lumbar spinal fusion has been developed and is nowadays a common procedure for unstable degenerative spine disorders. In the past several years, studies that highlight the importance of sagittal balance analysis with the restoration of adequate lumbar lordosis, have emerged. However, it remains a challenge to determine the correct amount of lumbar lordosis that is required for each patient to maintain optimal post-fusion sagittal balance. Additionally, the relationship between pelvic incidence (PI) and impact of LL correction has been highlighted in literature. The position of fused vertebrae is of paramount importance, as sagittal alignment should be done with minimizing muscle work during posture. Failure to reach proper sagittal balance can result in compensatory mechanisms such as increased pelvic tilt (PT), cervical and thoracic segment hyperextension, and knee flexion. These compensatory mechanisms have adverse effects such as chronic pain, disability and muscle fatigue. With this study the investigators aim to analyze long-term clinical and spinopelvic radiographic parameter outcomes of patients who underwent a one-level spinal fusion procedure for single level degenerative spondylolisthesis disease at a single institution.

NCT ID: NCT03757702 Completed - Fibromyalgia Clinical Trials

Trunk Position Sense, Postural Stability and Spinal Posture in Fibromyalgia

Start date: July 10, 2018
Phase:
Study type: Observational

This study aims to investigate trunk position sense, postural stability and spine posture in fibromyalgia patients and healthy women.

NCT ID: NCT02994030 Completed - Clinical trials for Duchenne Muscular Dystrophy

Biomarker for Duchenne Muscular Dystrophy

BioDuchenne
Start date: August 20, 2018
Phase:
Study type: Observational

International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.

NCT ID: NCT02903459 Completed - Lordosis Clinical Trials

Analyze the Relationship Between the Density of Fat Tissue and Cellulite With the Lumbar Lordosis Degree

Start date: June 2016
Phase: N/A
Study type: Observational

The aim of this study is analyze the relationship between the density of visceral and subcutaneous fat and cellulite with the lumbar lordosis degree.

NCT ID: NCT01111019 Completed - Hypochondroplasia Clinical Trials

Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With Hypochondroplasia, Treated at Least 3 Years or Until Near Final Height, When Applicable, in Comparison With a Historic Cohort of Non-treated Children

Start date: March 21, 2006
Phase: Phase 2
Study type: Interventional

This study is conducted to describe the efficacy and safety of recombinant human growth hormone (r-hGH) treatment Saizen® on children with hypochondroplasia.

NCT ID: NCT00320619 Completed - Scoliosis Clinical Trials

Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery

Start date: September 2000
Phase: N/A
Study type: Interventional

Individuals who undergo spine surgery often have a significant loss of blood and may require multiple blood transfusions. Research has shown that epsilon-aminocaproic acid (EACA) may reduce the amount of blood lost during surgery, which would decrease the number of blood transfusions required. This study will evaluate the safety and effectiveness of EACA at reducing blood loss and the need for blood transfusions in individuals undergoing spine surgery.