End-Stage Renal Disease Clinical Trial
Official title:
Head-to-Head Comparison of Thymoglobulin vs. Campath-1H vs. Our Standard Center Treatment Protocol in Living Donor Renal Transplantation - A Study to Evaluate the Avoidance of Long-term Nephrotoxic Calcineurin Inhibitor Therapy
The purpose of this study is to observe in a randomized prospective study the effectiveness and toxicity of Thymoglobulin vs. Campath-1H used for induction therapy in recipients of living donor (LD) kidneys, compared with the investigators standard treatment protocol of Zenapax® and maintenance immunosuppression.
To observe in a randomized prospective pilot study the effectiveness and toxicity of
Thymoglobulin vs. Campath-1H used for induction therapy in recipients of living donor (LD)
kidneys, compared with our standard treatment protocol of Zenapax® and maintenance
immunosuppression (vide infra).
To determine the effect different antibody induction regimen on the lymphoid cell subsets of
the immune system in kidney allograft recipients peripheral blood and bone marrow aspirates
will be tested at surgery before transplantation and at intervals post operatively.
To treat renal transplant patients successfully in the absence of long-term calcineurin
inhibition to determine if there are beneficial effects on the prevention of chronic
allograft nephropathy.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
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