Complications of Pediatric Liver Transplantation

Liver Transplant; Complications Clinical Trial

Official title:

Early and Late Complications of Living Related Pediatric Liver Transplantation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04104971
• Other study ID #: liver transplantation
• Status: Recruiting
• Start date: January 2015
• Est. completion date: March 2021

Study information

• Verified date: September 2019
• Source: Assiut University
• Contact: Ahmed MN Mohamed, MD
• Phone: 01066778077
• Email: elhomosany2020[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Liver transplant is the treatment of choice in children with end-stage liver failure.liver transplant is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation.The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and in the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.

Description:

Liver transplant is the treatment of choice in children with end-stage liver failure. It involves the surgical removal of the entire organ, which is then replaced with a healthy donor liver. Having a healthy liver is essential to longevity because the liver is responsible for nutrient distribution and toxin removal in the body .

Living-donor liver transplantation has been developed to address the disparity between the number candidates for transplant and the reduced number of available organs for liver transplantation.

In general, liver transplant (LT) is indicated when the risk of mortality from the native liver disease outweighs the overall risk of transplantation. Indications for liver transplantation in children include malignant and non-malignant conditions.

The complications occur both immediately post-transplantation and in the long-term. The main complications in the immediate postoperative period are related to the function of the graft (dysfunction and rejection), the surgical technique, infections (bacterial, fungal, and viral),and systemic problems (pulmonary, renal, or neurological) and In the long term, the complications are typically a consequence of the prolonged immunosuppressive therapy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 45
• Est. completion date: March 2021
• Est. primary completion date: March 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 1 Year to 18 Years

Eligibility

Inclusion Criteria:

• All patients from (1- 18) years old who were prepared for liver transplantation and followed up at Yassin Abdel Ghaffar charity center for liver disease and research,Cairo,Egypt. from January 2015 to the end of March 2020.

Exclusion Criteria:

• Any patient who did not survive beyond the first post operative day.

Related Conditions & MeSH terms

• Liver Transplant; Complications

Intervention

Diagnostic Test:
• blood tests , abdominal US and doppler

Locations

Country	Name	City	State
Egypt	Assiut University Children Hospital	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Reuben A. Long-term management of the liver transplant patient: diabetes, hyperlipidemia, and obesity. Liver Transpl 2001; 7(Suppl 1): S13-21. Bucuvalas, J., Long-term outcomes in pediatric liver transplantation. Liver Transpl, 2009. 15Suppl 2: p. S6-11.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	hematological ,vascular and infectious complications	Number of patients have vascular complications Number of patients have pancytopenia Number of patients have bacterial viral or fungal infection any changes in septic screen of the patient	5 years