Retrograde Reperfusion Versus Antegrade Liver Transplant Reperfusion

Liver Transplant Failure Clinical Trial

Official title:

A Propensity Score Matched Pair Analysis of Retrograde Reperfusion Versus Antegrade Liver Transplant Reperfusion

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03846089
• Other study ID #: 106793
• Status: Withdrawn
• Start date: January 1, 2002
• Est. completion date: February 28, 2020

Study information

• Verified date: April 2022
• Source: London Health Sciences Centre
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A retrospective cohort analysis was performed comparing patients that had intra operative antegrade liver reperfusions versus patients that had retrograde liver perfusion.

Description:

A retrospective cohort analysis was performed comparing patients that had intra operative antegrade liver reperfusions versus patients that had retrograde liver perfusion. Antegrade Reperfusion(ATR) group: after completing the caval replacement or piggy-back, for IVC anastomosis, Portal vein (PV) anastomosis was done with a running suture as normal fashion, then it was followed by the removal the clamps, starting by the supra hepatic VC, followed by the PV clamp and finally the infrahepatic VC. It was followed by arterial anastomosis and the biliary anastomosis (duct-to-duct if possible). Retrograde group (RETR): after completing the piggyback the IVC was declamped immediately and retrograde low pressure reperfusion of the graft with low oxygenated venous blood was established. Central venous pressure was intended to be higher than in 8 mmHg to enable appropriate retrograde reperfusion in the transplanted liver. Significant venous backflow via portal vein appears immediately after declamping. Venous bleeding from the liver except portal backflow was stopped immediately after declamping the venous anastomosis, as appropriate. Portal vein anastomosis was performed using running suture. It was followed by arterial anastomosis and the biliary anastomosis (duct-to-duct if possible). The endpoints are patient survival and graft survival at 1, 3,5, 10 years post liver transplantation in both groups. To adjust for a selection bias, we will perform a propensity score analysis.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: February 28, 2020
• Est. primary completion date: December 31, 2005
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years and older

Eligibility

Inclusion Criteria:

• all liver transplantations between 1 Jan 2002 and 31 Dec 2005

Exclusion Criteria:

• liver retransplantation

• multiorgan transplantation

• ABO incompatible transplantation

Related Conditions & MeSH terms

• Liver Transplant Failure

Intervention

Procedure:
• Graft reperfusion
antegrade (forward) or retrograde (backward) blood reperfusion of the liver graft

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
London Health Sciences Centre

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Graft survival	Average length of time the liver graft remains in a living recipient regardless of function	From date of transplantation until the date of next transplantation or date of death from any cause, whichever came first, assessed up to 300 months
Secondary	Patient survival	Average length of time a recipient is alive regardless of presence of the second liver	From date of transplantation until the date of death from any cause assessed up to 300 months