Liver Transplant Abscess Clinical Trial
Official title:
Risk Factors and Outcomes of Pyogenic Liver Abscess in Adult Liver Recipients: A Match Case Control Study
Objective: the aim of this study is to identify risk factors associated with the development
of pyogenic liver abscesses (PLA) in adult liver recipients (ALR) and to describe the
experience of the Hospital Italiano de Buenos Aires (HIBA) in the diagnosis and therapeutic
management of these patients.
Background: adult liver recipients differ from the general population with PLA as they
exhibit: reconstructed biliary anatomy, recurrent hospitalizations, regular performance
status and are subjected to immunosuppression. However, the scientific evidence regarding
PLA developed in transplanted organs is still scarce and the management of this disease
continues to be based on experience in non-transplanted patients.
Methods: between 1996 and 2016, 879 adult patients underwent liver transplantation (LT) at
our institution. Patients who developed PLA after LT (cases) and controls are matched
according to the time from transplant to abscess in a 1 to 5 relation. The investigators
performed a logistic regression model to establish PLA risk factors considering clusters for
matched cases and controls. Independent risk factors will be identified using multivariate
regression analysis.
| Status | Recruiting |
| Enrollment | 126 |
| Est. completion date | March 3, 2017 |
| Est. primary completion date | March 2, 2017 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Patients older than 18 years of age with a history of univisceral liver transplantation since January 2002 for any cause and who have undergone medical follow-up at HIBA and had at least one event of liver abscess after transplantation. Exclusion Criteria: - Patients who died during the hospitalization of the transplant. Patients with parasitic, fungal or amoebic abscesses were excluded. Those patients with subdiaphragmatic or subhepatic abscesses, tumors with abscessed central necrosis were not included in the study either. Patients who underwent liver transplantation at another institution and were then admitted to hospital with a diagnosis of AHP were not included. |
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Hospital Italiano de Buenos Aires, Peron 4190 | Ciudad Autonoma de Buenos Aires | Capital Federal |
| Lead Sponsor | Collaborator |
|---|---|
| Hospital Italiano de Buenos Aires |
Argentina,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Development of a pyogenic liver abscess after liver transplantation | The diagnosis of hepatic abscess was based on clinical findings, evidence obtained from imaging studies, blood cultures, purulent material obtained from punctures, intraoperative findings and resolution after antibacterial chemotherapy, and one of the following scenarios could be found: to. Findings of one or more intrahepatic images of liquid characteristics by means of ultrasound and / or CT scan associated with suspected hepatic abscess based on the clinical picture, laboratory tests and / or microbiological study. B. Finding one or more intrahepatic images of liquid characteristics by means of US and / or CT, with posterior drainage of pus. |
January 1996 and December 2016 |