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NCT00698399 Clinical Trial

Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients

Liver Transplant Clinical Trial

Official title:
Serum Markers of Ischemia Reperfusion Injury in Liver Transplant Patients, Phase II

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00698399
Other study ID # 80237
Secondary ID
Status Completed
Phase N/A
First received June 12, 2008
Last updated February 27, 2018
Start date March 2008
Est. completion date February 2, 2010

Study information
Verified date February 2018
Source Vanderbilt University Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is an observational study examining serum markers in patients who are undergoing either a cadaveric liver transplant or a living related liver transplant.

Description:

The Departments of Anesthesiology are conducting an observational trial of markers in the serum of patients who are undergoing liver transplantation surgery. This study will utilize the biological markers, trimethylamine-N-oxide (TMAO), NGAL, and cystatin-C, sensitive markers of renal medullary injury in the blood and allantoin, a marker of oxidative stress as indicators of renal injury in a kidney during liver transplants. It is hypothesized that: (1) these markers are less pronounced in living donor liver transplant recipient patients than in cadaveric liver transplant recipients, and (2) these markers are less pronounced in cadaveric liver transplant recipients in which a "piggy-back" technique was used versus recipients in which a total venous occlusion technique was used. This study will be done in a multi-center format, along with researchers at UCSF

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date February 2, 2010
Est. primary completion date February 2, 2010
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- American Society of Anesthesiologists (ASA) Class I-V.

- Patient is undergoing elective Liver Transplant Surgery.

- Patient is an adult, 18 years old or older.

Exclusion Criteria:

- Patients < 18 Years of Age

- Patients who are pregnant

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Vanderbilt University Medical Center Nashville Tennessee

Sponsors (2)
Lead Sponsor Collaborator
Vanderbilt University Medical Center University of California, San Francisco

Country where clinical trial is conducted

United States, 

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