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Liver Surgery clinical trials

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NCT ID: NCT05594641 Recruiting - Liver Surgery Clinical Trials

Lactate Clearance After RIPC in Liver Resection

ARAGON
Start date: November 16, 2022
Phase: N/A
Study type: Interventional

The primary aim of the study is the evaluation of the efficacy of remote ischemic preconditioning (RIPC) in terms of increase of the clearance of lactates 4 hours after the end of the hepatic resection. The secondary aims of the study are represented by the evaluation of the patients' postoperative recovery and the restoration of a normal lactate metabolism.

NCT ID: NCT05116735 Completed - Liver Surgery Clinical Trials

Biliary Fistula and Late Recurrence of Liver Hydatid Cyst: Role of Cysto-biliary Communication

Start date: September 2010
Phase: N/A
Study type: Interventional

Purpose : The primary goals of this study were to determine the prevalence and risk factors of occult CBC and recurrence, as well as the relationship between occult cysto-biliary communications manifested as postoperative biliary leakage and recurrence. The secondary goal was to use chemical analysis of hydatid cyst fluid to assess excessive bilirubin and alkaline phosphatase levels as predictors of fistula and recurrence. Methods: This prospective multi-center experimental and follow-up study of six years duration was conducted at the hepato-biliary pancreatic units of our universities hospitals from September 2010 to September 2016. Initially, 292 patients were included, but only 244 patients enrolled in the final study.

NCT ID: NCT04668391 Completed - Liver Surgery Clinical Trials

Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament for Analgesia After Open Liver Surgery

Start date: December 17, 2020
Phase: N/A
Study type: Interventional

This is a prospective, randomized, controlled, noninferiority trial for evaluating the efficacy of ultrasound-guided anterior quadratus lumborum block at the lateral supra-arcuate ligament versus thoracic epidural analgesia after open liver surgery.

NCT ID: NCT04092608 Completed - Liver Surgery Clinical Trials

Restrictive vs Goal Directed Fluid Therapy During Hepatobiliary Surgery

Start date: September 4, 2019
Phase: N/A
Study type: Interventional

"Restrictive" fluid management is usually the current standard practice for patients undergoing liver surgery. The general idea is to maintain a low central venous pressure in order to decrease blood loss and improve the quality of the surgical field. However, this strategy , considered as rather "restrictive", can be associated with patient's harm, mainly acute kidney injury. Today, Goal directed fluid therapy (GDFT) is a well accepted strategy to optimize fluid administration in patients undergoing major surgery which aimed to maintain normovolemia without being too liberal. The goal of this randomized controlled trial is to compare these two strategies on Urethral Perfusion index measured with a new IKORUS UP probe (Foley catheter made smarter with embedded photoplethysmographic sensing technology).

NCT ID: NCT03793933 Completed - Hepatectomy Clinical Trials

ACS-NSQIP Calculator for Liver Surgery

Start date: November 1, 2015
Phase:
Study type: Observational

The American College of Surgeons National Surgical Quality Improvement Program's (ACS-NSQIP) calculator has been endorsed by the surgeons' community to counsel patients and relatives regarding estimated postoperative complications. However, it does not include organ-specific risks. The aim of this study was to assess the ACS-NSQIP calculator's ability to predict complications, mortality and length of stay (LOS) in patients undergoing hepatectomy for liver tumors

NCT ID: NCT03686137 Recruiting - Liver Surgery Clinical Trials

Institut Paoli Calmettes Hepatic Surgery Database

BDD CHIRHEP
Start date: November 6, 2017
Phase:
Study type: Observational

Database of patients who undergo hepatic surgery for: benign diseases, primary or secondary liver cancer at Institut Paoli-Calmettes

NCT ID: NCT03270917 Active, not recruiting - Liver Surgery Clinical Trials

ORANGE SEGMENTS: Open Versus Laparoscopic Parenchymal Preserving Postero-Superior Liver Segment Resection

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The international and multicentre ORANGE SEGMENTS - Trial is a prospective, double blinded, randomized controlled study comparing patients undergoing parenchymal preserving resection of postero-superior liver segments (involving one or two of segments 4a, 7, 8). All patients will be participating in an enhanced recovery programme. Primary outcome is time to functional recovery. Secondary study parameters include hospital length of stay, intraoperative blood loss, operation time, liver specific morbidity, readmission percentage, resection margin, quality of life, body image and cosmesis , reasons for delay of discharge after functional recovery, long term incidence of incisional hernias, hospital and societal costs during one year, time to adjuvant chemotherapy initiation, overall five-year survival.

NCT ID: NCT02993640 Completed - Liver Surgery Clinical Trials

Optimization of Hepatic Hemodynamics During Liver Surgery

Start date: September 2016
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to determine if vasopressin and nitroglycerin in combination will affect hepatic hemodynamics, in the setting of liver surgery.

NCT ID: NCT02715427 Recruiting - Liver Surgery Clinical Trials

Enhanced Recovery After Hepatic Surgery (MultiPAS).

MultiPAS
Start date: April 2016
Phase: N/A
Study type: Interventional

Enhanced rehabilitation programs are based on new therapies and treatment combinations to reduce the length of hospitalization, duration of postoperative convalescence, morbidity, but also the overall cost of care. The operating stress and hypercatabolic conditions surrounding the surgery are sources of complications. In this enhanced rehabilitation approach, the principle is to fight through a series of actions against this surgical stress. Several North American studies, Chinese, Scandinavian or Batavian have shown the feasibility and the interest of enhanced perioperative rehabilitation in liver surgery. Nevertheless, there is not until now French data concerning the assessment of enhanced rehabilitation in liver surgery. The main objective of the study is to compare the effectiveness of the implementation of a multimodal management program after liver surgery in a French university center compared to conventional care. Secondary objectives of the study are to compare an enhanced rehabilitation program in liver surgery versus conventional treatment in terms of morbidity and mortality in the immediate postoperative period and until day 90, length of hospital stay, blood loss and the delay to bowel mobility recovery. Compliance to the program in both groups will also be evaluated.

NCT ID: NCT02050841 Completed - Cardiac Surgery Clinical Trials

Octaplas Pediatric Plasma Replacement Trial

Start date: December 2014
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate the safety, tolerability and efficacy of octaplas in pediatric patients who require replacement of multiple coagulation factors. Replacement of multiple coagulation factors in pediatric patients with acquired deficiencies due to liver disease and/or in pediatric patients requiring cardiac surgery or liver surgery.