Liver Fibrosis Clinical Trial
The non-invasive assessment of liver fibrosis in chronic viral hepatitis B and C is now
entering clinical practice. It is based on blood tests, especially FibroMetre® and
Fibrotest® and on elastography with the Fibroscan®. Despite the overall satisfactory
diagnostic performance for all of these tests (AUROC ranging from 0.80 to 0.90 depending on
the study) for the discrimination of F≤1 versus F≥2, the positive and negative predictive
values , however, are far from be perfect in a given patient. With these technique, failures
are also possible and the measures do not meet quality standards that increase the risk of
misclassification. It would be particularly useful to have new generation techniques with a
better diagnostic performance.
In this project, in response to the problems presented above, we propose to evaluate the
diagnostic performance of five innovative ultrasonic techniques for the non-invasive
diagnosis of fibrosis.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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