Clinical Trials Logo
  1. Home
  2. Liver Dysfunction
  3. NCT04511507
  4. Details
NCT04511507 Clinical Trial

CytoSorb in Patients With Liver Failure

Liver Dysfunction Clinical Trial

Official title:
Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Liver Failure

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04511507
Other study ID # Cyto-ALF
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 10, 2016
Est. completion date August 30, 2021

Study information
Verified date September 2021
Source Institutul Clinic Fundeni
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Hemoadsorption has been demonstrated to improve liver functional tests in patients with liver failure. The present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with acute liver failure, on liver functional tests, severity scores and 30-days mortality. Paraclinical results and severity scores were obtained before and after the three consecutive sessions.

Recruitment information / eligibility
Status Completed
Enrollment 35
Est. completion date August 30, 2021
Est. primary completion date August 30, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - patients with acute liver failure or acute on chronic liver failure who require hemoadsorption in accordance with local guidelines Exclusion Criteria: - unsigned informed consent - duration of therapy under 12 hours - death before the three consecutive sessions

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• hemoadsorption
three consecutive sessions of hemoadsorption in patients with liver failure

Locations
Country Name City State
Romania Fundeni Clinical Institute Bucharest

Sponsors (1)
Lead Sponsor Collaborator
Institutul Clinic Fundeni

Country where clinical trial is conducted

Romania, 

Outcome
Type Measure Description Time frame Safety issue
Primary 30 days mortality 30 days mortality 30 days
See also
  Status Clinical Trial Phase
Completed NCT02754219 - Pharmacokinetics and Safety of Evogliptin in Subjects With Hepatic Dysfunction Phase 1
Terminated NCT01079104 - Hepa Wash Treatment of Patients With Hepatic Dysfunction in Intensive Care Units N/A
Recruiting NCT00553553 - Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery N/A
Completed NCT03641872 - A Validation Cohort for ACLF Diagnosis and Prognosis
Completed NCT03371537 - Study of Hemodynamic Conditions Measured During Hepatectomy
Not yet recruiting NCT05559242 - Pharmacokinetic Study of Anlotinib Hydrochloride Capsules in Healthy Subjects and Liver Dysfunction Patients Phase 1
Recruiting NCT02473601 - Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis Phase 2
Completed NCT01000337 - Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol N/A
Completed NCT03155984 - Optimizing HBV Management During Anti-CD20 Antibodies
Recruiting NCT06126419 - Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration N/A
Completed NCT03515980 - An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function Phase 1
Completed NCT01338714 - The Effect of Compound Herbal Formula (RHD-1) on HBV Carrier With Abnormal Liver Function Phase 3
Completed NCT02005744 - A Pharmacokinetic Study of CKD-501 in Patients With Impaired Hepatic Function Phase 1
Completed NCT01367522 - Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone in Volunteers With Impaired Hepatic Function Phase 1
Recruiting NCT03805139 - Role of Ajwa Derived Polyphenols in Dyslipidaemias N/A
Enrolling by invitation NCT05082077 - Global Utilization And Registry Database for Improved preservAtion of doNor Livers
Completed NCT02949505 - Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation N/A
Completed NCT02991339 - The Effects of Dexamethasone Administration on Jaundice Following Liver Resection Phase 2/Phase 3
Completed NCT02992639 - Weight Loss Effect on Circulating Liver Enzymes N/A
Recruiting NCT05793203 - Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients