Egyptian Liver Library: Rebuilding the Pyramid of Liver Disease Evidence in Egypt

Liver Diseases Clinical Trial

— ELL  

Official title:

Egyptian Liver Library: Rebuilding the Pyramid of Liver Disease Evidence in Egypt

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04465747
• Other study ID #: MB-2
• Status: Completed
• Start date: January 2016
• Est. completion date: January 2018

Study information

• Verified date: July 2020
• Source: Al-Azhar University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A lot of publications about liver disease are available worldwide. Egypt is one of the countries having a large number of publications in hepatology. There are defects in reviewing this evidence and making use of it. Addressing the areas of weakness in liver research in Egypt is challenging to researchers and clinicians. Creating a library for liver disease evidence in Egypt can solve this problem and lead future research in hepatology in Egypt.

Description:

Egypt is considered one of the countries with large liver disease burden in the world being endemic with bilharziasis and hepatitis C for decades. Limitations in health care resource further augment the magnitude of the problem allowing the development of disease specific complications in absence of effective treatments over the past. With discovery of anti-schistosomal therapy and implementation of the national program for eliminating bilharziasis; bilharzial liver disease incidence regressed markedly. However; complications of bilharzial liver disease are still present. The situation has been repeated with hepatitis C which is still a major health problem in Egypt regardless of the availability of highly effective interferon free antiviral regimens. This is mainly due to the large number of infected patients (estimated to be more than 6 million) [1], re-infection and presence of complications that needs further management. The need for addressing these major health problems in Egypt provoked a lot of research in the field of hepatology. Egyptian and non-Egyptian researchers have published a lot of scientific reports about liver diseases in Egypt. Since the ancient age of the pharaohs there were written evidence about liver disease in Egypt. It was reported in the Ebres Papyrus (around 2600 BC) that hardness of the liver occurs secondary to excess alcohol ingestion [2]. This was one of the oldest documented detailed medical literatures in the history of mankind. In the recent age there were a lot reports from Egypt about bilharziasis and other parasitic infestations as the one published by Cobbold in 1982 about injurious parasites in Egypt [3]. Further enormous amount of publications has been released afterwards. Reviewing this evidence and creating an indexed data base for it could be of value for the national and international hepatology platforms. I aim with other colleagues at reviewing all published evidence in the field of hepatology from Egypt up to January 2016 and classifying it by different key words to build a data base of liver disease evidence in Egypt. This data base will be continuously updated by published data after January 1st 2016 and will be the reference for researchers from Egypt and rest of the world. The data base will invite all authors from Egypt to provide their raw data of published articles to be available for further analyses by other researchers. Moreover the data base work team will start a series of systematic reviews and meta analyses for the available relevant data aiming at addressing the areas of strength and areas of weakness in liver disease research in Egypt making further recommendations to the research authorities about what is missing and how it is better to be addressed in their future research calls. This pilot research work can be reproduced elsewhere by other researchers in their own countries making use of their published data and advising their local research authorities to fill up the gaps in liver research in their own countries. Hopefully in the near future we will have these groups working together in a network driving liver research globally.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5068
• Est. completion date: January 2018
• Est. primary completion date: January 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Published articles about liver disease up to January 2016

Exclusion Criteria:

• Anything else

Related Conditions & MeSH terms

• Liver Diseases

Intervention

Other:
• Publications
Reviewing published evidence

Locations

Country	Name	City	State
Egypt	Al-Azhar Uinversity	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Al-Azhar University

Country where clinical trial is conducted

Egypt, 

References & Publications (3)

Bruggmann, P., Berg, T., Øvrehus, A. L. H., Moreno, C., Brandão Mello, C. E., Roudot-Thoraval, F., Marinho, R. T., Sherman, M., Ryder, S. D., Sperl, J., Akarca, U., Balik, I., Bihl, F., Bilodeau, M., Blasco, A. J., Buti, M., Calinas, F., Calleja, J. L., Cheinquer, H., Christensen, P. B., Clausen, M., Coelho, H. S. M., Cornberg, M., Cramp, M. E., Dore, G. J., Doss, W., Duberg, A. S., El-Sayed, M. H., Ergör, G., Esmat, G., Estes, C., Falconer, K., Félix, J., Ferraz, M. L. G., Ferreira, P. R., Frankova, S., García-Samaniego, J., Gerstoft, J., Giria, J. A., Gonçales, F. L., Gower, E., Gschwantler, M., Guimarães Pessôa, M., Hézode, C., Hofer, H., Husa, P., Idilman, R., Kåberg, M., Kaita, K. D. E., Kautz, A., Kaymakoglu, S., Krajden, M., Krarup, H., Laleman, W., Lavanchy, D., Lázaro, P., Marotta, P., Mauss, S., Mendes Correa, M. C., Müllhaupt, B., Myers, R. P., Negro, F., Nemecek, V., Örmeci, N., Parkes, J., Peltekian, K. M., Ramji, A., Razavi, H., Reis, N., Roberts, S. K., Rosenberg, W. M., Sarmento-Castro, R., Sarrazin, C., Semela, D., Shiha, G. E., Sievert, W., Stärkel, P., Stauber, R. E., Thompson, A. J., Urbanek, P., van Thiel, I., Van Vlierberghe, H., Vandijck, D., Vogel, W., Waked, I., Wedemeyer, H., Weis, N., Wiegand, J., Yosry, A., Zekry, A., Van Damme, P., Aleman, S. and Hindman, S. J. (2014), Historical epidemiology of hepatitis C virus (HCV) in selected countries. Journal of Viral Hepatitis, 21: 5-33. doi: 10.1111/jvh.12247

Cobbold TS. Remarks on Injurious Parasites of Egypt in Relation to Water-Drinking. Br Med J. 1882 Sep 16;2(1133):503-4. — View Citation

Starr SP, Raines D. Cirrhosis: diagnosis, management, and prevention. Am Fam Physician. 2011 Dec 15;84(12):1353-9. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Review of all published articles about liver disease in Egypt till April 2017	Indexing articles according to types of liver disease	1 year
Secondary	Identifying missing diseases in hepatology research in Egypt	Identifying missing diseases in hepatology research in Egypt	1 year