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NCT03563404 Clinical Trial

Portal Blood Flushes in the Peri-Reperfusion Stage of Liver Transplantation

Liver Disease Clinical Trial

Official title:
Are Portal Blood Flushes Useful in Maintaining Hemodynamic Stability in the Peri-Reperfusion Stage of Orthotopic Liver Transplantation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03563404
Other study ID # Pro00044952
Secondary ID
Status Completed
Phase
First received
Last updated
Start date June 29, 2015
Est. completion date June 29, 2016

Study information
Verified date July 2018
Source Medical University of South Carolina
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

By showing that increased levels of acidotic metabolites and electrolytes in the systemic blood of patients who do not receive portal blood flush prior to reperfusion compared to patients who do receive portal blood flush, and that these increased levels correlate with cardiac depression as seen on TEE, the investigators hope to find a superior technique for liver reperfusion.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date June 29, 2016
Est. primary completion date June 29, 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Liver Transplantation

- 18 years old or older

Exclusion Criteria:

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Medical University of South Carolina Charleston South Carolina

Sponsors (1)
Lead Sponsor Collaborator
Medical University of South Carolina

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Hemodynamic Stability The primary objective of this study is to determine whether or not a portal blood flush is useful for maintaining hemodynamic stability in the peri-reperfusion stage of Orthotopic Liver Transplantation as evidence by TEE. 5 days
Secondary correlation between the cardiac dysfunction and the degree of hyperkalemia seen after reperfusion. The secondary objective is to determine if there is a correlation between cardiac dysfunction as measured by a qualitative analysis of TEE and the degree of hyperkalemia measured by a post reperfusion blood sample. 5 days
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