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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01220986
Other study ID # NDDC10/H0403/32
Secondary ID
Status Recruiting
Phase N/A
First received October 13, 2010
Last updated October 13, 2010
Start date August 2010
Est. completion date August 2012

Study information

Verified date October 2010
Source Nottingham University Hospitals NHS Trust
Contact John S Hammond, BM.BS PhD
Phone 01159249924
Email john.hammond@nottingham.ac.uk
Is FDA regulated No
Health authority United Kingdom: Research Ethics Committee
Study type Observational

Clinical Trial Summary

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.


Recruitment information / eligibility

Status Recruiting
Enrollment 20
Est. completion date August 2012
Est. primary completion date December 2011
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria:

- Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria:

- Age >75, neoadjuvant chemotherapy, recurrent disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Procedure:
Liver biopsy
0, 30, 60, 90 min post inflow-division

Locations

Country Name City State
United Kingdom Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus Nottingham Nottinghamshire

Sponsors (1)

Lead Sponsor Collaborator
Nottingham University Hospitals NHS Trust

Country where clinical trial is conducted

United Kingdom, 

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