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SASL Swiss Cirrhosis Cohort — SSCiCoS  

Liver Cirrhosis Clinical Trial

Official title:
SASL Swiss Cirrhosis Cohort Study

Clinical Trial Summary

This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and patient-reported data and biobank biological material from patients with cirrhosis. The central element of all scientific operation and productivity in the Swiss Cirrhosis Cohort Study (SSCiCoS) is the so-called "nested project" (NP). Based on the evolving large pool of data and biological samples, SSCiCoS investigators use the data pool in order to investigate specific hypotheses and questions.

Clinical Trial Description

For patients with end-stage cirrhosis there are no treatment options other than transplantation, a medically and ethically challenging procedure. The challenge therefore is to prevent the need for liver transplantation in as many patients with cirrhosis as possible. In order to reach this aim, patients with cirrhosis should be identified and followed regularly according to the highest standard of current knowledge. Numerous aspects of the disease need to be detailed: its epidemiology in Switzerland, its pathophysiology including the mechanism of scar tissue generation and resolution, the associated immune dysfunction and subsequent organ failures, disease related psychosocial and behavioural factors, perceived burden of liver cirrhosis in patients, diagnostic and prognostic biomarkers for disease dynamics, both progression and regression of disease, and stage-specific therapeutic strategies. This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and patient-reported data and biobank biological material from patients with cirrhosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06092385
Study type Observational
Source University Hospital, Basel, Switzerland
Contact Christine Bernsmeier, Prof. Dr. med.
Phone +41 61 265 2525
Email christine.bernsmeier@clarunis.ch
Status Recruiting
Phase
Start date January 20, 2023
Completion date January 2033
View Details
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