Observational Prospective Study.at the End of the Study the Patients Will be Classified According to PH,Serum Bicarbonate and Serum Sodium Into 6 Groups and Statistical Analysis Will be Performed Using Spss

Liver Cirrhosis Clinical Trial

Official title:

Impact of Serum Bicarbonate and Electrolytes on Adverse Outcomes in Decompensated Cirrhotic Patients in Sohag University Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05082064
• Other study ID #: liver cirrhosis
• Status: Completed
• Start date: October 8, 2021
• Est. completion date: January 7, 2023

Study information

• Verified date: January 2023
• Source: Sohag University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

1-to identify the prognostic value of serum bicarbonate and serum electrolytes at time of admission and their association with development of complications ,length of hospital stay ,prognosis and mortality in hospitalized cirrhotic patient

Description:

the purpose of this study will be explore the impact of data obtained for the arterial blood gas parameters and serum bicarbonate and electrolytes at the time of hospital admission on adverse clinical outcomes ,duration of length of hospital stay and mortality in patients with cirrhosis .Furthermore incorporation these parameters into model of end stage liver disease could help to improve the prognostic value of MELDscore in comparison to the prognostic value of traditional equation of original MELD and child score

Recruitment information / eligibility

• Status: Completed
• Enrollment: 121
• Est. completion date: January 7, 2023
• Est. primary completion date: December 8, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

patients with confirmed diagnosis of cirrhosis (age >18 years ) who will be admitted to internal medicine department or will be admitted to intermediate care unit

• willing and agree to be included in the study

Exclusion Criteria:

• patients without evidence of cirrhosis

• cirrhotic patients whom -younger than 18 years old

• have diabetic ketoacidosis

• with acute coronary syndrome

• with fulminant liver failure

• with heart failure

• with organ transplantation

• when arterial blood gases not be available

• patient refusal

• patient with HCC

Related Conditions & MeSH terms

• Liver Cirrhosis

Intervention

Diagnostic Test:
• arterial blood gases and serum electrolytes
arterial bloog gases parameters serum potassium serum sodium serum calcium

Locations

Country	Name	City	State
Egypt	Heba Allah fadel abd elrahman	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Scheiner B, Lindner G, Reiberger T, Schneeweiss B, Trauner M, Zauner C, Funk GC. Acid-base disorders in liver disease. J Hepatol. 2017 Nov;67(5):1062-1073. doi: 10.1016/j.jhep.2017.06.023. Epub 2017 Jul 3. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	will be ICU admitted	will be admitted to ICU due to progression of the disease; complications as shok,hepatorenal syndrome,severe infection,starting renal replacement therapy and icu intervention as mechanical ventilation using MELD score and child score depending on ABGparameters and serum electrolytes .	from the day of admission to the day of discharge from hospital or death during hospitalization