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Efficacy and Safety of Anticoagulant Therapy in Portal Vein Thrombosis

Liver Cirrhosis Clinical Trial

Official title:
Efficacy and Safety of Nadroparin Calcium-Warfarin Sequential Anticoagulation in Portal Vein Thrombosis in Cirrhotic Patients：A Randomized Controlled Trial

Clinical Trial Summary

The study is aimed at evaluating the efficacy and safety of anticoagulant therapy with nadroparin calcium and warfarin in patients with portal vein thrombosis (PVT).

Clinical Trial Description

Portal vein thrombosis (PVT) is a frequent complication of liver cirrhosis, referred to partial or complete thrombosis formed in the lumen of portal vein or/and branches of it. Currently, clinical guidelines of PVT in cirrhotic patients has not been addressed, and anticoagulant therapy of PVT patients with cirrhosis remains controversial. Although numerable studies have reported that anticoagulation therapy is effective, while a majority of them were respective and a few took control into consideration. In addition, no agreement has reached about the safety of anticoagulation. So, the efficacy and safety of anticoagulant therapy needs more prospective randomized controlled trial to be investigated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04173429
Study type Interventional
Source Qilu Hospital of Shandong University
Contact
Status Completed
Phase Phase 4
Start date January 1, 2017
Completion date January 31, 2020
View Details
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