Liver Cirrhosis Clinical Trial
Official title:
Role of Bone Marrow Derived Autologous Stem Cells + Human Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Liver Cirrhosis
Cirrhosis is caused by sustained liver damage over several years either by alcohol, viral
infection (Hepatitis B, C), a toxic substance (for eg. drugs, excess copper or iron in the
liver), or by blockage of biliary system such that the liver undergoes progressive scarring
that slowly replaces all of normal liver cells.(LC) represents a late stage of progressive
hepatic fibrosis characterized by distortion of the hepatic architecture and formation of
regenerative nodules. For this condition of disease the liver transplantation is one of the
only effective therapies available ,but due to lack of donors, surgical complications,
rejection, and high cost are it`s serious problems.
Presently stem cells are used to be a one of the treatment for the same. So our approach is
to evaluate the safety and efficacy of mesenchymal stem cell in condition of liver cirrhosis
.
In this study, the patients with liver cirrhosis will undergo administration of human Mesenchymal stem cell MSCs intravenously for these patients.To observe the results Liver function will be monitored by serum analysis.The levels of serum alanine aminotransferase (ALT), total bilirubin (TB), prothrombin time (PT), prealbumin(PA) and albumin (ALB) will be examined at pre-transfusion, and 6th days to 1 years post-transfusion.Also the to see Improvement evaluation by MELD score ,Quality of life ,Child-Pugh score will be done . ;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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