Lipid Metabolism Clinical Trial
Official title:
Patterns and Plasticity of Orthotopic and Ectopic Fat Deposition and Associations With Insulin Sensitivity: A Magnetic-resonance-imaging and -Spectroscopy Study in Lean and Obese Individuals: Methodological Part
Verified date | August 2013 |
Source | University Hospital Inselspital, Berne |
Contact | n/a |
Is FDA regulated | No |
Health authority | Switzerland: Ethikkommission |
Study type | Observational |
The main goal of the present study was to provide a technical basis for future studies
assessing the role of cardiac lipids. More specifically, non-invasive MR-Spectroscopy (MRS)
techniques will be used in this study to:
1. assess the methodological reproducibility of MRS-measurements of cardiac lipids in
humans
2. investigate physiological variations of cardiac lipids by measuring day-to-day changes
under identical conditions
3. determining diurnal variations of cardiac lipids in humans
Status | Completed |
Enrollment | 9 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - male - age 18-30 - BMI <25 - healthy - written informed consent Exclusion Criteria: - contraindications to MRI examinations (claustrophobia, implanted devices (pacemaker, insulin pump, neurostimulators)) |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Switzerland | Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital Bern | Bern |
Lead Sponsor | Collaborator |
---|---|
University Hospital Inselspital, Berne | Takeda |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intramyocardial lipid content | at baseline (morning of examination day 1) | No | |
Secondary | Intramyocardial lipid content | evening of examination day 1, i.e. 8 hours after baseline | No | |
Secondary | Intramyocardial lipid content | morning of examination day 2, i.e. 7 days after baseline | No | |
Secondary | Intramyocardial lipid content | evening of examination day 2, i.e. 7 days & 8 hours after baseline | No | |
Secondary | Intra-individual variation of intramyocardial lipid content | Difference between evening and morning measurement within examination day one | evening of examination day one, i.e. 8 hours after baseline | No |
Secondary | Intra-individual variation of intramyocardial lipid content | Difference between evening and morning measurement within examination day two | evening of examination day two, i.e. 7 days & 8 hours after baseline | No |
Secondary | Intra-individual difference of intramyocardial lipid content (morning) over one week | Difference between morning measurements of examination day 1 and examination day 2 | morning of examination day one, i.e. 7 days after baseline | No |
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