Effect of High-calcium Intake on Substrate Metabolism During Exercise

Lipid Metabolism Clinical Trial

Official title:

The Impact of a Calcium Supplementation on Lipid Metabolism During Exercise.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01779245
• Other study ID #: 32AN3
• Status: Completed
• Phase: N/A
• First received: January 28, 2013
• Last updated: September 4, 2013
• Start date: October 2012
• Est. completion date: February 2013

Study information

• Verified date: September 2013
• Source: Northumbria University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

A high-calcium intake can accelerate fat loss under energy-restricted diets. Part of this may be due to a shift in substrate metabolism where there is an increase in the rate of fat oxidation. However, whether high-calcium intake can influence substrate metabolism during exercise is not known. Accordingly, we aim to investigate the effect of 2 weeks of high-calcium intake on substrate metabolism during exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: February 2013
• Est. primary completion date: February 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Physically active (moderate-vigorous exercise >3 time per week)

• Male

• 18-40 yrs of age

Exclusion Criteria:

• Smoker

• Known Food Allergies

• Metabolic disorders

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Lipid Metabolism

Intervention

Dietary Supplement:
• Calcium
Milk-extracted calcium supplement will be used to modulate the calcium content of the milkshakes used.
• Placebo

Locations

Country	Name	City	State
United Kingdom	Northumbria University	Newcastle upon Tyne	Tyne and Wear

Sponsors (1)

Lead Sponsor	Collaborator
Northumbria University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Serum parathyroid hormone concentration	Parathyroid hormone concentrations will be determined at rest before and after supplementation periods as a indicator of calcium status.	Baseline (Pre-post 2 week supplementation)	No
Other	Plasma glucose-dependent insulinotropic peptide concentration	Glucose-dependent insulinotropic peptide concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.	Baseline (Pre-post 2 week supplementation)	No
Other	Plasma glucagon-like peptide-1 concentration	Glucagon-like peptide-1 concentrations will be determined at rest before and after supplementation periods as a potential mechanism of any changes in metabolism.	Baseline (Pre-post 2 week supplementation)	No
Primary	Substrate metabolism	Substrate metabolism will be assessed by the respiratory exchange ratio (rate of carbon dioxide production/rate of oxygen consumption) from samples of expired gas collected during the first 15 minutes of an incremental cycling test.	60 s samples every 3 min for 15 min	No
Secondary	Plasma non-esterified fatty acid concentrations	Non-esterified fatty acid concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test to indicate fatty acid availability.	Every 3 min for 15 min	No
Secondary	Plasma glycerol concentrations	Glycerol concentrations will be determined from plasma samples collected during the first 15 minutes of an incremental cycling test as a marker of lipolysis.	Every 3 min for 15 min	No