Lipedema Clinical Trial
Official title:
Evaluation of Lipoedema Tissue Transcriptome
NCT number | NCT05861583 |
Other study ID # | Lipo2023 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2023 |
Est. completion date | March 1, 2024 |
Lipoedema is a chronic painful disease with a fat distribution disorder affecting women. It is probably aggravated by hormonal changes. It is also discussed that a genetical predisposition might be a risk factor for developing lipoedema. The mechanisms leading to lipoedema are mostly unknown. The aim of this study is to identify molecular mechanisms and changes of the RNA-Expression pattern causing lipoedema by comparing the transcriptome of subcutaneous tissue of lipoedema patients vs. healthy subcutaneous tissue.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | March 1, 2024 |
Est. primary completion date | December 1, 2023 |
Accepts healthy volunteers | |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: 1. Lipohypertrophy: tissue from healthy patients (n=20): Consent-capable female patients =18 years of age with lipohypertrophy 2. Lipoedema milde stage: tissue from Lipoedema patients with mild stage 1 (n=20): Consent-capable female patients =18 years of age with Lipoedema (Stage 1) 3. Lipoedema moderate stage: tissue from Lipoedema patients with moderate stage 2 (n=20): Consent-capable female patients =18 years of age with Lipoedema (Stage 2) 4. Lipoedema severe stage: tissue from Lipoedema patients with severe stage 3 (n=20): Consent-capable female patients =18 years of age with Lipoedema (Stage 3) Exclusion Criteria: - Inflammation in region of interest, HIV, Hepatitis |
Country | Name | City | State |
---|---|---|---|
Germany | University of Schleswig-Holstein | Lübeck | Schleswig-Holstein |
Lead Sponsor | Collaborator |
---|---|
University Hospital Schleswig-Holstein | Hanse-Klinik, Fachklinik für Liposuktion, Lübeck, Praxisklinik Kronshagen, Kiel-Kronshagen |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Differences in RNA-Expression pattern | Differences in RNA-Expression pattern between lipoedema tissue and lipohypertrophy tissue | 1 day |
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