Treatment of Women With Lipedema Involving Substantial Fat Above the Knee or of Women and Men With Nodular Dercum's Disease

Lipedema Clinical Trial

Official title:

An Open Label, Phase 2a Clinical Trial for the Evaluation of Safety and Efficacy of RZL-012 for the Treatment of Women With Lipedema Involving Substantial Fat Above the Knee or of Women and Men With Nodular Dercum's Disease

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04076891
• Other study ID #: RZL-012-FD-P2aUS-001.7
• Status: Completed
• Phase: Phase 2
• Start date: June 28, 2018
• Est. completion date: May 2, 2019

Study information

• Verified date: September 2019
• Source: Raziel Therapeutics Ltd.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is an open label, 2 cohort, clinical trial in women with lipedema with substantial fat above the knee or women and men with nodular Dercum's disease. Each cohort will have 6 subjects who will receive RZL-012.

Description:

This is an open label, 2 cohort clinical trial in women with lipedema with substantial fat above the knee or women and men with nodular Dercum's disease. Each cohort will have 6 subjects who will receive RZL-012.

• The 1st cohort will be comprised of subjects with Dercum's disease

• The 2nd cohort will be comprised of subjects with lipedema with substantial fat above the knee.

Within each cohort, dosing of the subjects will progress consecutively from one individual to the other with a minimum of 7-days between subjects to assess safety. This study design will allow the physicians to monitor safety for at least 7 days prior to dosing the next subject. Cohort 2 will be conducted in a dose escalation manner and the decision to proceed to the next dose level will be made after reviewing all safety data collected by Day 14 within 2 ± 1d of the last dosed subject. The trial will proceed within a cohort provided that no more than one subject experiences intolerable side effects in a cohort, and based on the decision made by the Principal Investigator (PI) and the Medical Monitor.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: May 2, 2019
• Est. primary completion date: May 2, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 65 Years

Eligibility

Inclusion Criteria:

• 1. Post-menopausal (at least 2 years) women no more than 65 years old, with lipedema involving substantial fat above the knee or nodular Dercum's disease in such women and in men 20 - 65 years with nodular Dercum's disease.

2. For Dercum's disease subjects - at least 2 nodules to be injected of at least 2cm diameter each, as determined by ultrasound 3. For lipedema subjects - Significant subcutaneous fat above the knee as determined by circumference of 50cm 4. Generally considered healthy according to medical history, physical examination, ECG and laboratory evaluation with a special emphasis on metabolic parameters (fasting glucose concentration < 200 mg, normal blood pressure).

5. Subjects must be able to adhere to the visit schedule and protocol requirements and be available to complete the study.

6. Subjects must sign an informed consent indicating that they are aware of the investigational nature of the study.

Exclusion Criteria:

• 1. Unable to tolerate subcutaneous injection. 2. Subjects with uncontrolled cardiac, hepatic, renal or neurologic/psychiatric disorders, that in the opinion of the investigator, put the subject at significant risk, are not eligible.

3. Positive blood screen for Hepatitis B surface antigen (HbSAg), Hepatitis C virus (HCV), or Human immunodeficiency virus (HIV), or positive urine screen for alcohol or drugs of abuse (unless prescribed by a physician).

4. Subjects with a clinical history of primary or secondary immunodeficiency, autoimmune disease or subjects taking immunosuppressive drugs such as corticosteroids are ineligible.

5. As a result of medical review, physical examination, the PI (or medically qualified nominee) considers the subject unfit for the study.

6. Known sensitivity to components of the injection formulation. 7. Prior wound, tattoo or infection in the treated area. 8. Prior invasive treatment such as surgery or injectable drug at the RZL-012 injected area.

Related Conditions & MeSH terms

• Dercum Disease
• Lipedema

Intervention

Drug:
• RZL-012
The dosing regimen will be a single dose treatment injection of RZL-012 in multiple sites.

Locations

Country	Name	City	State
United States	University of Arizona Clinical and Translational Science Research Center	Tucson	Arizona

Sponsors (1)

Lead Sponsor	Collaborator
Raziel Therapeutics Ltd.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The incidence of any Grade 3 or greater event intolerable side effect experienced in a cohort	Trial will proceed as long as no more than one subject experiences an intolerable side effect in a cohort	To 14 days