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Linear IgA Bullous Dermatosis clinical trials

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NCT ID: NCT02493283 Completed - Methemoglobinemia Clinical Trials

Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration

Start date: September 2011
Phase: Phase 1
Study type: Interventional

The objectives of the study are - to evaluate pharmacokinetics, distribution in blood leucocytes, metabolism and methemoglobinemia after single-dose and repeated-dose administration of 100 mg of dapsone in healthy subjects genotyped for CYP2C9 and NAT2 - to evaluate serum through levels, distribution in blood leucocytes and methemoglobinemia after repeated-dose treatment with dapsone in patients with autoimmune bullous dermatoses before and after concomitant treatment with glucocorticoids

NCT ID: NCT01952275 Recruiting - Clinical trials for Pyoderma Gangrenosum

Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases

NEUTROGENE
Start date: January 2014
Phase: N/A
Study type: Observational

This study investigates the genetic architecture of Neutrophil-Mediated Inflammatory Skin Diseases. After collecting informed consent, all patients' clinical phenotype is graded at inclusion with a detailed case report form and a discovery cohort formed based on the certainty of diagnosis. The DNA of patients in the discovery cohort is analyzed by whole exome sequencing which identifies all protein-coding genetic variants. Subsequently, statistical burden tests are going to identify enrichment of rare coding genetic variants in patients affected by Neutrophil-Mediated Inflammatory Skin Diseases. The ultimate goal is to reveal the responsible gene(s) that may then be targets for clinical intervention.